G
Gennadij Raivich
Researcher at University College London
Publications - 108
Citations - 10089
Gennadij Raivich is an academic researcher from University College London. The author has contributed to research in topics: Axotomy & Microglia. The author has an hindex of 54, co-authored 107 publications receiving 9483 citations. Previous affiliations of Gennadij Raivich include Max Planck Society & Imperial College London.
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Journal ArticleDOI
Neuroglial activation repertoire in the injured brain: graded response, molecular mechanisms and cues to physiological function.
Gennadij Raivich,Marion Bohatschek,Christian U.A. Kloss,Alexander Werner,Leonard L. Jones,Georg W. Kreutzberg +5 more
TL;DR: Recent work in mice that are genetically deficient for different cytokines (MCSF, IL1, IL6, TNFalpha, TGFbeta1) has begun to shed light on the molecular signals that regulate this cellular response.
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Experimental autoimmune encephalomyelitis repressed by microglial paralysis.
Frank L. Heppner,Melanie Greter,Denis Marino,Jeppe Falsig,Gennadij Raivich,Nadine Hövelmeyer,Ari Waisman,Thomas Rülicke,Marco Prinz,Marco Prinz,Josef Priller,Burkhard Becher,Adriano Aguzzi +12 more
TL;DR: The results validate CD11b-HSVTK mice as a tool to study the impact of microglial activation on CNS diseases in vivo and conclude that microglia paralysis inhibits the development and maintenance of inflammatory CNS lesions.
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c-Jun Reprograms Schwann Cells of Injured Nerves to Generate a Repair Cell Essential for Regeneration
Peter Arthur-Farraj,Morwena Latouche,D Wilton,Susanne Quintes,Elodie Chabrol,Annbily Banerjee,Ashwin Woodhoo,Billy Jenkins,Mary Rahman,Mark Turmaine,Grzegorz Wicher,Richard Mitter,Linda Greensmith,Axel Behrens,Gennadij Raivich,Rhona Mirsky,Kristjan R. Jessen +16 more
TL;DR: It is concluded that a single glial transcription factor is essential for restoration of damaged nerves, acting to control the transdifferentiation of myelin and Remak Schwann cells to dedicated repair cells in damaged tissue.
Journal ArticleDOI
The AP-1 Transcription Factor c-Jun Is Required for Efficient Axonal Regeneration
Gennadij Raivich,Marion Bohatschek,Clive Da Costa,Osuke Iwata,Matthias Galiano,Maria Hristova,Abdolrahman S. Nateri,Milan Makwana,Lluís Riera-Sans,David P. Wolfer,Hans-Peter Lipp,Adriano Aguzzi,Erwin F. Wagner,Axel Behrens +13 more
TL;DR: C-Jun is identified as an important regulator of axonal regeneration in the injured central nervous system and Expression of CD44, galanin, and alpha7beta1 integrin was greatly impaired, suggesting a mechanism for c-Jun-mediated axonal growth.
Journal ArticleDOI
Immune Surveillance in the Injured Nervous System: T-Lymphocytes Invade the Axotomized Mouse Facial Motor Nucleus and Aggregate around Sites of Neuronal Degeneration
Gennadij Raivich,Leonard L. Jones,Christian U.A. Kloss,Alexander Werner,Harald Neumann,Georg W. Kreutzberg +5 more
TL;DR: In this paper, the lymphocyte infiltration, a key component of this neuroimmune surveillance, into the axotomized facial motor nucleus and analyzed the changes in proinflammatory cytokines and the blood-brain barrier.