L
Leonid Gorelik
Researcher at Biogen Idec
Publications - 44
Citations - 9534
Leonid Gorelik is an academic researcher from Biogen Idec. The author has contributed to research in topics: JC virus & Progressive multifocal leukoencephalopathy. The author has an hindex of 30, co-authored 44 publications receiving 9104 citations. Previous affiliations of Leonid Gorelik include Yale University.
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Journal ArticleDOI
Abrogation of TGFβ Signaling in T Cells Leads to Spontaneous T Cell Differentiation and Autoimmune Disease
TL;DR: It is shown that T cell homeostasis requires T GFβ signaling in T cells, and a transgenic approach to abrogate the TGFβ response in key immune cells is developed.
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Transforming growth factor-beta in T-cell biology.
TL;DR: In vitro studies provide a better understanding of how TGF-β regulates T-cell homeostasis, through multiple mechanisms involving numerous cell types, and advances in cell-specific targeting of T GF-β signalling in vivo clearer.
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Immune-mediated eradication of tumors through the blockade of transforming growth factor-beta signaling in T cells.
TL;DR: It is demonstrated here that T-cell–specific blockade of TGF-β signaling allows the generation of an immune response capable of eradicating tumors in mice challenged with live tumor cells.
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Regulatory T cells suppress tumor-specific CD8 T cell cytotoxicity through TGF-β signals in vivo
Mei Ling Chen,Mikael J. Pittet,Leonid Gorelik,Leonid Gorelik,Richard A. Flavell,Ralph Weissleder,Harald von Boehmer,Khashayarsha Khazaie +7 more
TL;DR: Monitoring the homing, expansion, and effector function of both subsets in draining and nondraining lymph nodes shows that CD8 cells expand to the same extent and produce similar levels of IFN-γ in the presence or absence of Ag-specific Treg, which abrogate CD8 T cell-mediated tumor rejection by specifically suppressing the cytotoxicity of expandedCD8 cells.
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T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells.
Linda Fahlén,Simon Read,Leonid Gorelik,Stephen D. Hurst,Robert L. Coffman,Richard A. Flavell,Fiona Powrie +6 more
TL;DR: It is shown that CD4+CD25+ T reg cells from the thymus of dnTβRII mice retain the ability to inhibit colitis, suggesting that T cell responsiveness to TGF-β is not required for the development or peripheral function of thymic-derived TReg cells.