S
Stephen D. Hurst
Researcher at Genentech
Publications - 28
Citations - 4857
Stephen D. Hurst is an academic researcher from Genentech. The author has contributed to research in topics: Cytokine & Antigen. The author has an hindex of 23, co-authored 27 publications receiving 4668 citations. Previous affiliations of Stephen D. Hurst include Northwestern University.
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Journal ArticleDOI
IL-25 induces IL-4, IL-5, and IL-13 and Th2-associated pathologies in vivo.
Madeline M. Fort,Jeanne Cheung,David C. Yen,Joana Li,Sandra Zurawski,Sylvia Lo,Satish Menon,Teresa Clifford,Brisdell Hunte,Robin Lesley,Tony Muchamuel,Stephen D. Hurst,Gerard Zurawski,Michael W. Leach,Daniel M. Gorman,Donna Rennick +15 more
TL;DR: The results suggest that IL-25, derived from Th2 T cells, is capable of amplifying allergic type inflammatory responses by its actions on other cell types.
Journal ArticleDOI
New IL-17 Family Members Promote Th1 or Th2 Responses in the Lung: In Vivo Function of the Novel Cytokine IL-25
Stephen D. Hurst,Tony Muchamuel,Daniel M. Gorman,Jonathan M. Gilbert,Theresa Clifford,Sylvia Kwan,Satish Menon,Brian W. P. Seymour,Craig Jackson,Ted T. Kung,Joan K. Brieland,Sandra Zurawski,Richard W. Chapman,Gerard Zurawski,Robert L. Coffman +14 more
TL;DR: The existence of a previously unrecognized cell population that may initiate Th2-like responses by responding to IL-25 in vivo is suggested and it is suggested thatIL-25 may be an important mediator of allergic disease via production of IL-4,IL-5, IL-13, and eotaxin.
Journal ArticleDOI
T cells that cannot respond to TGF-beta escape control by CD4(+)CD25(+) regulatory T cells.
Linda Fahlén,Simon Read,Leonid Gorelik,Stephen D. Hurst,Robert L. Coffman,Richard A. Flavell,Fiona Powrie +6 more
TL;DR: It is shown that CD4+CD25+ T reg cells from the thymus of dnTβRII mice retain the ability to inhibit colitis, suggesting that T cell responsiveness to TGF-β is not required for the development or peripheral function of thymic-derived TReg cells.
Journal Article
Differential CC chemokine-induced enhancement of T helper cell cytokine production.
William J. Karpus,Nicholas W. Lukacs,Kevin J. Kennedy,W S Smith,Stephen D. Hurst,T A Barrett +5 more
TL;DR: Results suggest CC chemokines play a role in regulating naive Th cell cytokine production, in addition to regulating leukocyte trafficking.
Journal ArticleDOI
IL-25 regulates Th17 function in autoimmune inflammation
Melanie A. Kleinschek,Alexander Owyang,Barbara Joyce-Shaikh,Claire L. Langrish,Yi Chen,Daniel M. Gorman,Wendy M. Blumenschein,Terrill K. McClanahan,Frank Brombacher,Stephen D. Hurst,Robert A. Kastelein,Daniel J. Cua +11 more
TL;DR: It is shown that IL-25 also regulates the development of autoimmune inflammation mediated by IL-17–producing T cells, and plays opposing roles in the pathogenesis of organ-specific autoimmunity.