L
Leonid Yurkovetskiy
Researcher at University of Massachusetts Medical School
Publications - 21
Citations - 2556
Leonid Yurkovetskiy is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 13, co-authored 16 publications receiving 1590 citations. Previous affiliations of Leonid Yurkovetskiy include University of Chicago.
Papers
More filters
Journal ArticleDOI
Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Leonid Yurkovetskiy,Xue Wang,Kristen E. Pascal,Christopher Tomkins-Tinch,Thomas Nyalile,Yetao Wang,Alina Baum,William E. Diehl,Ann Dauphin,Claudia Carbone,Kristen Veinotte,Shawn B. Egri,Stephen F. Schaffner,Stephen F. Schaffner,Jacob E. Lemieux,James B. Munro,Ashique Rafique,Abhi Barve,Pardis C. Sabeti,Christos A. Kyratsous,Natalya Dudkina,Kuang Shen,Jeremy Luban +22 more
TL;DR: It is shown that D614G was more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human ACE2 or of ACE2 orthologs from various mammals, including Chinese rufous horseshoe bat and Malayan pangolin.
Journal ArticleDOI
Gender Bias in Autoimmunity Is Influenced by Microbiota
Leonid Yurkovetskiy,Michael P. Burrows,Aly A. Khan,Laura Graham,Pavel Volchkov,Lev Becker,Dionysios A. Antonopoulos,Dionysios A. Antonopoulos,Yoshinori Umesaki,Alexander V. Chervonsky +9 more
TL;DR: Although protection of males did not correlate with blood androgen concentration, hormone-supported expansion of selected microbial lineages may work as a positive-feedback mechanism contributing to the sexual dimorphism of autoimmune diseases.
Posted ContentDOI
Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Leonid Yurkovetskiy,Xue Wang,Kristen E. Pascal,Christopher Tomkins-Tinch,Christopher Tomkins-Tinch,Thomas Nyalile,Yetao Wang,Alina Baum,William E. Diehl,Ann Dauphin,Claudia Carbone,Kristen Veinotte,Shawn B. Egri,Stephen F. Schaffner,Stephen F. Schaffner,Jacob E. Lemieux,Jacob E. Lemieux,James B. Munro,Ashique Rafique,Abhi Barve,Pardis C. Sabeti,Christos A. Kyratsous,Natalya Dudkina,Kuang Shen,Jeremy Luban +24 more
TL;DR: D614G adopts conformations that make virion membrane fusion with the target cell membrane more probable but that D614G retains susceptibility to therapies that disrupt interaction of the SARS-CoV-2 S protein with the ACE2 receptor.
Journal ArticleDOI
Analysis of 6.4 million SARS-CoV-2 genomes identifies mutations associated with fitness
Fritz Obermeyer,Martin Jankowiak,Nikolaos Barkas,Stephen F. Schaffner,Jesse D. Pyle,Leonid Yurkovetskiy,Matteo Bosso,Daniel J. Park,Mehrtash Babadi,Bronwyn L. MacInnis,Jeremy Luban,Pardis C. Sabeti,Jacob E. Lemieux +12 more
TL;DR: PyR0, a hierarchical Bayesian multinomial logistic regression model that infers relative prevalence of all viral lineages across geographic regions, detects lineages increasing in prevalence, and identifies mutations relevant to fitness, is developed.
Posted ContentDOI
SARS-CoV-2 Spike protein variant D614G increases infectivity and retains sensitivity to antibodies that target the receptor binding domain
Leonid Yurkovetskiy,Xue Wang,Kristen E. Pascal,Christopher Tompkins-Tinch,Thomas Nyalile,Yetao Wang,Alina Baum,William E. Diehl,Ann Dauphin,Claudia Carbone,Kristen Veinotte,Shawn B. Egri,Stephen F. Schaffner,Stephen F. Schaffner,Jacob E. Lemieux,Jacob E. Lemieux,James B. Munro,Ashique Rafique,Abhi Barve,Pardis C. Sabeti,Christos A. Kyratsous,Natalya Dudkina,Kuang Shen,Jeremy Luban +23 more
TL;DR: The results suggest that D614G was selected for increased human-to-human transmission, that it contributed to the rapidity of SARS-CoV-2 spread around the world, and that it does not confer resistance to antiviral therapies targeting the receptor binding domain.