K
Kuang Shen
Researcher at University of Massachusetts Medical School
Publications - 51
Citations - 6056
Kuang Shen is an academic researcher from University of Massachusetts Medical School. The author has contributed to research in topics: GTPase & mTORC1. The author has an hindex of 27, co-authored 42 publications receiving 4480 citations. Previous affiliations of Kuang Shen include University of Science and Technology of China & California Institute of Technology.
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Journal ArticleDOI
Sestrin2 is a leucine sensor for the mTORC1 pathway
Rachel L. Wolfson,Lynne Chantranupong,Robert A. Saxton,Kuang Shen,Sonia M. Scaria,Jason R. Cantor,David M. Sabatini +6 more
TL;DR: In this paper, it was shown that leucine, but not arginine, disrupts the Sestrin2-GATOR2 interaction with a dissociation constant of 20 micromolar.
Journal ArticleDOI
Structural and Functional Analysis of the D614G SARS-CoV-2 Spike Protein Variant.
Leonid Yurkovetskiy,Xue Wang,Kristen E. Pascal,Christopher Tomkins-Tinch,Thomas Nyalile,Yetao Wang,Alina Baum,William E. Diehl,Ann Dauphin,Claudia Carbone,Kristen Veinotte,Shawn B. Egri,Stephen F. Schaffner,Stephen F. Schaffner,Jacob E. Lemieux,James B. Munro,Ashique Rafique,Abhi Barve,Pardis C. Sabeti,Christos A. Kyratsous,Natalya Dudkina,Kuang Shen,Jeremy Luban +22 more
TL;DR: It is shown that D614G was more infectious than the ancestral form on human lung cells, colon cells, and on cells rendered permissive by ectopic expression of human ACE2 or of ACE2 orthologs from various mammals, including Chinese rufous horseshoe bat and Malayan pangolin.
Journal ArticleDOI
Lysosomal amino acid transporter SLC38A9 signals arginine sufficiency to mTORC1
Shuyu Wang,Zhi-Yang Tsun,Rachel L. Wolfson,Kuang Shen,Gregory A. Wyant,Molly Plovanich,Elizabeth D. Yuan,Tony D. Jones,Lynne Chantranupong,William C. Comb,Timothy C. Wang,Liron Bar-Peled,Roberto Zoncu,Christoph Straub,Choah Kim,Jiwon Park,Bernardo L. Sabatini,David M. Sabatini +17 more
TL;DR: SLC38A9, an uncharacterized protein with sequence similarity to amino acid transporters, is identified as a lysosomal transmembrane protein that interacts with the Rag guanosine triphosphatases and Ragulator in an amino acid–sensitive fashion and is an excellent candidate for being an arginine sensor for the mTORC1 pathway.
Journal ArticleDOI
The CASTOR Proteins Are Arginine Sensors for the mTORC1 Pathway
Lynne Chantranupong,Sonia M. Scaria,Robert A. Saxton,Melanie P. Gygi,Kuang Shen,Gregory A. Wyant,Timothy C. Wang,J. Wade Harper,Steven P. Gygi,David M. Sabatini +9 more
TL;DR: In this article, it was shown that CASTOR1, a previously uncharacterized protein, interacts with GATOR2 and is required for arginine deprivation to inhibit mTORC1.
Journal ArticleDOI
Signal Recognition Particle: An Essential Protein-Targeting Machine
TL;DR: Recent work is summarized that elucidates how the SRP and SRP receptor interact with the cargo protein and the target membrane, respectively, and how these interactions are coupled to a novel GTPase cycle in theSRP·SRP receptor complex to provide the driving force and enhance the fidelity of this fundamental cellular pathway.