L
Leroy-Fong Liu
Researcher at Johns Hopkins University
Publications - 21
Citations - 7161
Leroy-Fong Liu is an academic researcher from Johns Hopkins University. The author has contributed to research in topics: Topoisomerase & DNA. The author has an hindex of 20, co-authored 21 publications receiving 6997 citations.
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Camptothecin induces protein-linked DNA breaks via mammalian DNA topoisomerase I.
TL;DR: It is proposed that camptothecin blocks the rejoining step of the breakage-reunion reaction of mammalian DNA topoisomerase I, which results in the accumulation of a cleavable complex which resembles the transient intermediate proposed for eukaryotic DNATopoisomersase I.
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Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II
TL;DR: In studies in vitro, mammalian DNA topoisomerase II mediates DNA damage by adriamycin and other related antitumor drugs, and has been shown to induce single- and double-strand breaks in DNA.
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Intercalative antitumor drugs interfere with the breakage-reunion reaction of mammalian DNA topoisomerase II.
TL;DR: The agreement between the in vivo and in vitro studies suggests that mammalian DNA topoisomerase II is a drug target in vivo, and the cytotoxic action of epipodophyllotoxins may be analogous to the bactericidal action of nalidixic acid.
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Topoisomerase II is a structural component of mitotic chromosome scaffolds
TL;DR: The results suggest that topoisomerase II may be an enzyme that is also a structural protein of interphase nuclei and mitotic chromosomes, and an abundant nuclear enzyme that controls DNA topological states.
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Transcription-driven supercoiling of DNA: direct biochemical evidence from in vitro studies.
TL;DR: In vitro results provide direct biochemical evidence supporting the twin supercoiled domain model of transcription and suggest that transcription is one of the principal factors affecting intracellular DNA supercoiling.