L
Leslie D Wagner
Researcher at Center for Biologics Evaluation and Research
Publications - 6
Citations - 171
Leslie D Wagner is an academic researcher from Center for Biologics Evaluation and Research. The author has contributed to research in topics: Anthrax vaccines & Immunogenicity. The author has an hindex of 6, co-authored 6 publications receiving 150 citations.
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Immunogenicity in mice of anthrax recombinant protective antigen in the presence of aluminum adjuvants.
TL;DR: Results indicated that AlPO4 is able to significantly increase the antibody response to rPA, irrespective of its degree of adsorption to the adjuvant, which confirmed that, in this mouse model, binding of the protein to the adhesion molecule is not essential for adjUvanticity.
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Structural and Immunological Analysis of Anthrax Recombinant Protective Antigen Adsorbed to Aluminum Hydroxide Adjuvant
Leslie D Wagner,Anita Verma,Bruce D. Meade,Karine Reiter,David L. Narum,Rebecca A. Brady,Stephen F. Little,Drusilla L. Burns +7 more
TL;DR: It is demonstrated that storage of rPA-Alhydrogel formulations can lead to structural alteration of the protein and loss of the ability to elicit toxin-neutralizing antibodies.
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Maternal Vaccination With a Monocomponent Pertussis Toxoid Vaccine Is Sufficient to Protect Infants in a Baboon Model of Whooping Cough.
TL;DR: It is demonstrated that maternal vaccination with a PTx-only vaccine is sufficient to protect newborn baboons from disease following exposure to pertussis.
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Comparability of ELISA and toxin neutralization to measure immunogenicity of Protective Antigen in mice, as part of a potency test for anthrax vaccines.
TL;DR: Even though ELISA and TNA results showed correlation, ELISA results may not be able to accurately predict T NA results in this single immunization model.
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Role of the N-terminal amino acid of Bacillus anthracis lethal factor in lethal toxin cytotoxicity and its effect on the lethal toxin neutralization assay.
TL;DR: The cytotoxic activity of lethal factor, a critical reagent used in the cell-based lethal toxin neutralization assay to assess anthrax vaccines, was shown to depend on the identity of its N-terminal amino acid, which plays a role in the targeting of LF to the proteasome for degradation.