K
Karine Reiter
Researcher at National Institutes of Health
Publications - 29
Citations - 955
Karine Reiter is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Plasmodium falciparum & Antigen. The author has an hindex of 16, co-authored 26 publications receiving 794 citations.
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Journal ArticleDOI
Structure of the Plasmodium falciparum circumsporozoite protein, a leading malaria vaccine candidate.
Matthew L. Plassmeyer,Karine Reiter,Richard L. Shimp,Svetlana Kotova,Paul D. Smith,Darrell E. Hurt,Brent House,Xiaoyan Zou,Yanling Zhang,Merrit Hickman,Onyinyechukwu Uchime,Raul Herrera,Vu Nguyen,Jacqueline Glen,Jacob Lebowitz,Albert J. Jin,Louis H. Miller,Nicholas J. MacDonald,Yimin Wu,David L. Narum +19 more
TL;DR: In this paper, the structure of the four amino acid repeat region (NANP) of CSP was analyzed using high-resolution atomic force microscopy (OFM) and dynamic light scattering and velocity sedimentation.
Journal ArticleDOI
Conjugating recombinant proteins to Pseudomonas aeruginosa ExoProtein A: A strategy for enhancing immunogenicity of malaria vaccine candidates
Feng Qian,Yimin Wu,Olga Muratova,Hong Zhou,Gelu Dobrescu,Peter F. Duggan,Lambert Lynn,Guanhong Song,Yanling Zhang,Karine Reiter,Nicholas J. MacDonald,David L. Narum,Carole A. Long,Louis H. Miller,Allan Saul,Gregory E. D. Mullen +15 more
TL;DR: Results demonstrate that conjugation to rEPA induces a marked improvement in the antibody titer in mice for the poor immunogen (Pfs25) and for the larger protein (AMA1), and these conjugates now need to be tested in humans to determine if mice are predictive of the response in humans.
Journal ArticleDOI
Development of a Pfs25-EPA malaria transmission blocking vaccine as a chemically conjugated nanoparticle.
Richard L. Shimp,Christopher G. Rowe,Karine Reiter,Beth Chen,Vu Nguyen,Joan Aebig,Kelly M. Rausch,Krishan Kumar,Yimin Wu,Albert J. Jin,David S. Jones,David L. Narum +11 more
TL;DR: To overcome the poor immunogenicity, processes to produce and characterize recombinant Pfs25H conjugated to a detoxified form of Pseudomonas aeruginosa exoprotein A (EPA) have been developed and used to manufacture a cGMP pilot lot for use in human clinical trials.
Journal ArticleDOI
Structural and Immunological Characterization of Recombinant 6-Cysteine Domains of the Plasmodium falciparum Sexual Stage Protein Pfs230.
Nicholas J. MacDonald,Vu Nguyen,Richard L. Shimp,Karine Reiter,Raul Herrera,Martin Burkhardt,Olga Muratova,Krishan Kumar,Joan Aebig,Kelly M. Rausch,Lynn Lambert,Nikiah Dawson,Jetsumon Sattabongkot,Xavier Ambroggio,Patrick E. Duffy,Yimin Wu,David L. Narum +16 more
TL;DR: Rabbit antibodies generated against recombinant Pfs230 domains blocked mosquito transmission of a laboratory strain and two field isolates using an ex vivo assay, a significant step toward the potential development of a transmission blocking vaccine to eliminate malaria.
Journal ArticleDOI
Salivary Antigen-5/CAP Family Members Are Cu2+-dependent Antioxidant Enzymes That Scavenge O2⨪ and Inhibit Collagen-induced Platelet Aggregation and Neutrophil Oxidative Burst *
Teresa C.F. Assumpção,Dongying Ma,Alexandra Schwarz,Karine Reiter,Jaime M. Santana,John F. Andersen,José M. C. Ribeiro,Glenn Nardone,Lee L. Yu,Ivo M.B. Francischetti +9 more
TL;DR: Antigen-5/CAP emerges as a novel family of Cu2+-dependent antioxidant enzymes that inhibit neutrophil oxidative burst and negatively modulate platelet aggregation by a unique salivary mechanism.