L
Leslie J. Matthews
Researcher at Harvard University
Publications - 4
Citations - 932
Leslie J. Matthews is an academic researcher from Harvard University. The author has contributed to research in topics: Epitope & Peptide library. The author has an hindex of 4, co-authored 4 publications receiving 869 citations.
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Journal ArticleDOI
Potent neutralization of severe acute respiratory syndrome (SARS) coronavirus by a human mAb to S1 protein that blocks receptor association
Jianhua Sui,Wenhui Li,Akikazu Murakami,Azaibi Tamin,Leslie J. Matthews,Swee Kee Wong,Michael Moore,Aimee St. Clair Tallarico,Mobolaji Olurinde,Hyeryun Choe,Larry J. Anderson,William J. Bellini,Michael Farzan,Wayne A. Marasco +13 more
TL;DR: Data suggest that the 80R human monoclonal antibody may be a useful viral entry inhibitor for the emergency prophylaxis and treatment of SARS, and that the ACE2-binding site of S1 could be an attractive target for subunit vaccine and drug development.
Journal ArticleDOI
Peptides specific to the galectin-3 carbohydrate recognition domain inhibit metastasis-associated cancer cell adhesion
Jun Zou,Vladislav V. Glinsky,Vladislav V. Glinsky,Linda A. Landon,Leslie J. Matthews,Susan L. Deutscher,Susan L. Deutscher +6 more
TL;DR: Results demonstrate that carbohydrate-mediated, metastasis-associated tumor cell adhesion could be inhibited efficiently with short synthetic peptides which do not mimic naturally occurring glycoepitopes yet bind to the galectin-3 carbohydrate recognition domain with high affinity and specificity.
Journal ArticleDOI
Evaluation of Human Monoclonal Antibody 80R for Immunoprophylaxis of Severe Acute Respiratory Syndrome by an Animal Study, Epitope Mapping, and Analysis of Spike Variants
Jianhua Sui,Wenhui Li,Anjeanette Roberts,Leslie J. Matthews,Akikazu Murakami,Leatrice Vogel,Swee Kee Wong,Kanta Subbarao,Michael Farzan,Wayne A. Marasco +9 more
TL;DR: It is proposed that by establishing the susceptibility and resistance profiles of newly emerging SARS-CoVs through early S1 genotyping of the core 180-amino-acid neutralizing epitope of 80R, an effective immunoprophylaxis strategy with 80R should be possible in an outbreak setting.
Journal ArticleDOI
Mapping a neutralizing epitope on the SARS coronavirus spike protein: computational prediction based on affinity-selected peptides.
TL;DR: Screening of phage display random peptide libraries with a unique computer algorithm “Mapitope” is combined to identify the discontinuous epitope of 80R, a potent neutralizing human anti-SARS monoclonal antibody against the spike protein.