H
Hyeryun Choe
Researcher at Scripps Research Institute
Publications - 112
Citations - 26496
Hyeryun Choe is an academic researcher from Scripps Research Institute. The author has contributed to research in topics: Chemokine receptor & Coronavirus. The author has an hindex of 60, co-authored 110 publications receiving 23477 citations. Previous affiliations of Hyeryun Choe include Brigham and Women's Hospital & Pennsylvania State University.
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Journal ArticleDOI
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.
Wenhui Li,Michael Moore,Natalya Vasilieva,Jianhua Sui,Swee Kee Wong,Michael A. Berne,Mohan Somasundaran,John L. Sullivan,Katherine Luzuriaga,Thomas C. Greenough,Hyeryun Choe,Michael Farzan +11 more
TL;DR: It is found that a soluble form of ACE2, but not of the related enzyme ACE1, blocked association of the S1 domain with Vero E6 cells, indicating that ACE2 is a functional receptor for SARS-CoV.
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The β-Chemokine Receptors CCR3 and CCR5 Facilitate Infection by Primary HIV-1 Isolates
Hyeryun Choe,Michael Farzan,Ying Sun,Nancy Sullivan,Barrett J. Rollins,Paul D. Ponath,Lijun Wu,Charles R. Mackay,Gregory J. LaRosa,Walter Newman,Norma P. Gerard,Craig Gerard,Joseph Sodroski +12 more
TL;DR: The ability of various members of the chemokine receptor family to support the early stages of HIV-1 infection helps to explain viral tropism and beta-chemokine inhibition of primary HIV- 1 isolates.
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The lymphocyte chemoattractant SDF-1 is a ligand for LESTR/fusin and blocks HIV-1 entry.
Conrad C. Bleul,Michael Farzan,Hyeryun Choe,Cristina Parolin,Cristina Parolin,Ian Clark-Lewis,Joseph Sodroski,Timothy A. Springer +7 more
TL;DR: Testing of potential receptors demonstrated that SDF-1 signalled through, and hence 'adopted', the orphan receptor LESTR, which is therefore designated CXC-chemokine receptor-4 (CXCR-4).
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CD4-induced interaction of primary HIV-1 gp120 glycoproteins with the chemokine receptor CCR-5
Lijun Wu,Norma P. Gerard,Richard T. Wyatt,Hyeryun Choe,Cristina Parolin,Nancy Ruffing,Alessândra Borsetti,Angelo A. Cardoso,Elizabeth Desjardin,Walter Newman,Craig Gerard,Joseph Sodroski +11 more
TL;DR: It is suggested that HIV-1 attachment to CD4 creates a high-affinity binding site for CCR-5, leading to membrane fusion and virus entry.
Journal ArticleDOI
CCR3 and CCR5 are co-receptors for HIV-1 infection of microglia
Jianglin He,Youzhi Chen,Michael Farzan,Hyeryun Choe,Asa Ohagen,Suzanne Gartner,Jorge Busciglio,Jorge Busciglio,Xiaoyu Yang,Wolfgang Hofmann,Walter Newman,Charles R. Mackay,Joseph Sodroski,Dana Gabuzda +13 more
TL;DR: The CCR3 ligand, eotaxin, and an anti-CCR3 antibody inhibited HIV-1 infection of microglia, as did MIP-1β, which is a CCR5 ligand that promotes efficient infection of the CNS by HIV- 1.