W
Wenhui Li
Researcher at Tsinghua University
Publications - 98
Citations - 18284
Wenhui Li is an academic researcher from Tsinghua University. The author has contributed to research in topics: Hepatitis B virus & Coronavirus. The author has an hindex of 45, co-authored 90 publications receiving 14898 citations. Previous affiliations of Wenhui Li include Peking University & Beijing Normal University.
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Journal ArticleDOI
Angiotensin-converting enzyme 2 is a functional receptor for the SARS coronavirus.
Wenhui Li,Michael Moore,Natalya Vasilieva,Jianhua Sui,Swee Kee Wong,Michael A. Berne,Mohan Somasundaran,John L. Sullivan,Katherine Luzuriaga,Thomas C. Greenough,Hyeryun Choe,Michael Farzan +11 more
TL;DR: It is found that a soluble form of ACE2, but not of the related enzyme ACE1, blocked association of the S1 domain with Vero E6 cells, indicating that ACE2 is a functional receptor for SARS-CoV.
Journal ArticleDOI
Structure of SARS Coronavirus Spike Receptor-Binding Domain Complexed with Receptor
Fang Li,Wenhui Li,Wenhui Li,Michael Farzan,Michael Farzan,Stephen C. Harrison,Stephen C. Harrison +6 more
TL;DR: The structure of the RBD suggests ways to make truncated disulfide-stabilized RBD variants for use in the design of coronavirus vaccines.
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Sodium taurocholate cotransporting polypeptide is a functional receptor for human hepatitis B and D virus
Huan Yan,Guocai Zhong,Guangwei Xu,Wenhui He,Zhiyi Jing,Zhenchao Gao,Yi Huang,Yonghe Qi,Bo Peng,Haimin Wang,Liran Fu,Mei Song,Pan Chen,Wenqing Gao,Bijie Ren,Yinyan Sun,Tao Cai,Xiaofeng Feng,Jianhua Sui,Wenhui Li +19 more
TL;DR: It is shown that the receptor-binding region of pre-S1 specifically interacts with sodium taurocholate cotransporting polypeptide (NTCP), a multiple transmembrane transporter predominantly expressed in the liver that is a functional receptor for HBV and HDV.
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Receptor and viral determinants of SARS-coronavirus adaptation to human ACE2
Wenhui Li,Chengsheng Zhang,Chengsheng Zhang,Jianhua Sui,Jens H. Kuhn,Jens H. Kuhn,Michael Moore,Shiwen Luo,Swee-Kee Wong,I-Chueh Huang,Keming Xu,Natalya Vasilieva,Akikazu Murakami,Yaqing He,Wayne A. Marasco,Yi Guan,Hyeryun Choe,Michael Farzan +17 more
TL;DR: Comparisons of S proteins of SARS‐CoV isolated during the 2002–2003 SARS outbreak and during the much less severe 2003–2004 outbreak, and from palm civets, provide insight into the severity of the 2002‐ 2003 SARS epidemic.
Journal ArticleDOI
SARS-CoV-2 spike-protein D614G mutation increases virion spike density and infectivity
Lizhou Zhang,Cody B. Jackson,Huihui Mou,Amrita Ojha,Haiyong Peng,Brian D. Quinlan,Erumbi S. Rangarajan,Andi Pan,Abigail Vanderheiden,Mehul S. Suthar,Wenhui Li,Tina Izard,Christoph Rader,Michael Farzan,Hyeryun Choe +14 more
TL;DR: Pseudoviruses carrying SG614 enter ACE2-expressing cells more efficiently than those with SD614, and D614G may increase infectivity by assembling more functional S protein into the virion.