L
Leslie M. Loew
Researcher at University of Connecticut
Publications - 288
Citations - 19918
Leslie M. Loew is an academic researcher from University of Connecticut. The author has contributed to research in topics: Membrane & Membrane potential. The author has an hindex of 68, co-authored 276 publications receiving 18813 citations. Previous affiliations of Leslie M. Loew include Cornell University & University of Connecticut Health Center.
Papers
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Journal ArticleDOI
Intracellular fluorescent probe concentrations by confocal microscopy.
TL;DR: A general method is described that takes advantage of the optical sectioning properties of a confocal microscope to enable measurement of both absolute and relative concentrations of fluorescent molecules inside cells.
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Cholesterol-enriched lipid domains can be visualized by di-4-ANEPPDHQ with linear and nonlinear optics.
TL;DR: A membrane-staining dye, di-4-ANEPPDHQ, which differentiates liquid-ordered phases from liquid-disordered phases coexisting in model membranes under both linear and nonlinear microscopies, should lead to broad applications in biophysical studies of lipid domains inmodel membranes and cells.
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Optogenetics design of mechanistically-based stimulation patterns for cardiac defibrillation
Claudia Crocini,Cecilia Ferrantini,Raffaele Coppini,Marina Scardigli,Ping Yan,Leslie M. Loew,Godfrey L. Smith,Elisabetta Cerbai,Corrado Poggesi,Francesco S. Pavone,Leonardo Sacconi +10 more
TL;DR: It is demonstrated that defibrillation energies can be substantially reduced by applying discrete stimulation patterns and promotes the progress of current anti-arrhythmic strategies.
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Membrane Electric Properties by Combined Patch Clamp and Fluorescence Ratio Imaging in Single Neurons
TL;DR: The combination of electrical and optical methods can also follow changes in other membrane electric properties, such as dipole potential, and thus permit a detailed analysis of the membrane electrical properties underlying the voltage regulation of ion channels.
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Molecular machines or pleiomorphic ensembles: signaling complexes revisited.
TL;DR: Signaling complexes typically consist of highly dynamic molecular ensembles that are challenging to study and to describe accurately, and conventional mechanical descriptions misrepresent this reality and can be actively counterproductive by misdirecting us towards investigating critical issues.