L
Leslie W. Tari
Researcher at University of Calgary
Publications - 49
Citations - 2640
Leslie W. Tari is an academic researcher from University of Calgary. The author has contributed to research in topics: Periplasmic space & Transferrin. The author has an hindex of 22, co-authored 49 publications receiving 2474 citations. Previous affiliations of Leslie W. Tari include Takeda Pharmaceutical Company.
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Journal ArticleDOI
Structural Snapshots of Human HDAC8 Provide Insights into the Class I Histone Deacetylases
John R. Somoza,Robert J. Skene,Bradley A. Katz,Clifford D. Mol,Joseph D. Ho,Andrew John Jennings,Christine Luong,Andrew S. Arvai,Joseph J. Buggy,Ellen Chi,Jie Tang,Bi-Ching Sang,Erik Verner,Robert Wynands,Ellen M. Leahy,D.R. Dougan,Gyorgy Snell,Marc Navre,Mark W. Knuth,Ronald V. Swanson,Duncan E. McRee,Leslie W. Tari +21 more
TL;DR: The first crystal structures of a humanHDAC are described: the structures of human HDAC8 complexed with four structurally diverse hydroxamate inhibitors, which sheds light on the catalytic mechanism of the HDACs, and on differences in substrate specificity across theHDAC family.
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Plant aromatic L-amino acid decarboxylases: evolution, biochemistry, regulation, and metabolic engineering applications
TL;DR: A comprehensive survey of the extensive literature relevant to the evolution, physiology, biochemistry, regulation, and genetic engineering applications of plant aromatic L-amino acid decarboxylases (AADCs) is presented.
Journal ArticleDOI
Structural Basis for Bisphosphonate-mediated Inhibition of Isoprenoid Biosynthesis
David J. Hosfield,Yanming Zhang,D.R. Dougan,Alexei Broun,Leslie W. Tari,Ronald V. Swanson,John Finn +6 more
TL;DR: Crystal structures of substrate and bisphosphonate complexes of FPPS provide a structural template for the design of novel inhibitors that may prove useful for the treatment of osteoporosis and other clinical indications including cancer.
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Structural biology of bacterial iron uptake systems.
TL;DR: The current structures for iron transport proteins provide rational starting points for design of novel antimicrobial agents and complement knowledge of iron transport systems from other pathogenic bacteria, including Pseudomonas aeruginosa, which has a number of homologous iron uptake proteins.
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X-ray crystallographic structures of the Escherichia coli periplasmic protein FhuD bound to hydroxamate-type siderophores and the antibiotic albomycin.
TL;DR: In this paper, the authors used x-ray crystallography to determine the structures of FhuD with the antibiotic albomycin, the fungal siderophore coprogen and the drug Desferal.