Letizia Venturini

TL;DR: BCR-ABL- and c-MYC-dependent regulation of miRNA expression in chronic myeloid leukemia (CML) is reported using microarray analysis (miCHIP) and miRNA-specific quantitative real-time reverse transcriptase-polymerase chain reaction (miR-qRT-PCR).

TL;DR: The induction of stable loss-of-function phenotypes for specific miRNAs by lentivirus-mediated antagomir expression is described and inhibition of miRNA function correlates to reduction of ‘miRNA’ amplification by miRNA-specific quantitative RT-PCR.

TL;DR: This study identifies a novel pathophysiological circuit in the heart between reduced STAT3 protein levels, increased miR-199a expression, and subsequent impairment of the UPS that disrupts CM sarcomere structure and impairs via the release of ADMA endothelial cell function.

TL;DR: Analysis of miR17-92 in T-ALL patients indicated elevated expression in those bearing TLX1/3 positive cells, and data support an activatory effect of NK-like homeodomain proteins on pri-miR-17- 92 expression and concomitantly reduced E2F1 protein levels, thereby enhancing survival of leukemic T-cells.

TL;DR: Analysis of homeobox gene expression in Hodgkin lymphoma cell lines identified up-regulation of HOXB9 in HL mediated by constitutively active ERK5 signaling which may represent novel therapeutic targets in HL.