K
Karin Battmer
Researcher at Hannover Medical School
Publications - 45
Citations - 2738
Karin Battmer is an academic researcher from Hannover Medical School. The author has contributed to research in topics: RNA interference & Haematopoiesis. The author has an hindex of 23, co-authored 45 publications receiving 2581 citations. Previous affiliations of Karin Battmer include Heidelberg University & University of Tübingen.
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Journal ArticleDOI
High-level transduction and gene expression in hematopoietic repopulating cells using a human imunodeficiency virus type 1-based lentiviral vector containing an internal spleen focus forming virus promoter
Christophe Demaison,Kathryn L. Parsley,Gaby Brouns,Michaela Scherr,Karin Battmer,Christine Kinnon,Manuel Grez,Adrian J. Thrasher +7 more
TL;DR: A vesicular stomatitis virus G envelope protein (VSV-G)-pseudotyped human immunodeficiency virus type 1 (HIV-1) lentiviral-based vector system is used to transduce cord blood (CB) CD34+ cells over a limited time period and significant gene marking was observed in engrafted human lymphoid, myeloid, and progenitor cells in all transplanted Severe Combined Immunodeficient mice.
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Expression of the miR-17-92 polycistron in chronic myeloid leukemia (CML) CD34+ cells
Letizia Venturini,Karin Battmer,Mirco Castoldi,Beate Schultheis,Andreas Hochhaus,Martina U. Muckenthaler,Arnold Ganser,Matthias Eder,Michaela Scherr +8 more
TL;DR: BCR-ABL- and c-MYC-dependent regulation of miRNA expression in chronic myeloid leukemia (CML) is reported using microarray analysis (miCHIP) and miRNA-specific quantitative real-time reverse transcriptase-polymerase chain reaction (miR-qRT-PCR).
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Specific inhibition of bcr-abl gene expression by small interfering RNA
Michaela Scherr,Michaela Scherr,Karin Battmer,Karin Battmer,Thomas Winkler,Thomas Winkler,Olaf Heidenreich,Olaf Heidenreich,Arnold Ganser,Arnold Ganser,Matthias Eder,Matthias Eder +11 more
TL;DR: It is demonstrated that siRNA can specifically and efficiently interfere with the expression of an oncogenic fusion gene in hematopoietic cells.
Journal ArticleDOI
Lentivirus-mediated antagomir expression for specific inhibition of miRNA function
Michaela Scherr,Letizia Venturini,Karin Battmer,Michael Schaller-Schoenitz,Daniel Schaefer,Iris Dallmann,Arnold Ganser,Matthias Eder +7 more
TL;DR: The induction of stable loss-of-function phenotypes for specific miRNAs by lentivirus-mediated antagomir expression is described and inhibition of miRNA function correlates to reduction of ‘miRNA’ amplification by miRNA-specific quantitative RT-PCR.
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LEF-1 is crucial for neutrophil granulocytopoiesis and its expression is severely reduced in congenital neutropenia
Julia Skokowa,Gunnar Cario,Murat Uenalan,Axel Schambach,Manuela Germeshausen,Karin Battmer,Cornelia Zeidler,Ulrich Lehmann,Matthias Eder,Christopher Baum,Rudolf Grosschedl,Martin Stanulla,Michaela Scherr,Karl Welte +13 more
TL;DR: It is demonstrated here that lymphoid enhancer-binding factor 1 (LEF-1) mediates the proliferation, survival and differentiation of granulocyte progenitor cells and is an instructive factor regulating neutrophilic granulopoiesis whose absence plays a critical role in the defective maturation program of myeloid progenitors in individuals with CN.