L
Li Chai
Researcher at Brigham and Women's Hospital
Publications - 76
Citations - 5727
Li Chai is an academic researcher from Brigham and Women's Hospital. The author has contributed to research in topics: Haematopoiesis & SALL4. The author has an hindex of 28, co-authored 74 publications receiving 4684 citations. Previous affiliations of Li Chai include Rhode Island Hospital & Harvard University.
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Journal ArticleDOI
Patients with Cancer Appear More Vulnerable to SARS-CoV-2: A Multicenter Study during the COVID-19 Outbreak.
Meng-Yuan Dai,Dianbo Liu,Dianbo Liu,Miao Liu,Fuxiang Zhou,Gui-Ling Li,Zhen Chen,Zhi-An Zhang,Hua You,Meng Wu,Qi-Chao Zheng,Yong Xiong,Hui-Hua Xiong,Chun Wang,Chang-Chun Chen,Fei Xiong,Yan Zhang,Ya-Qin Peng,Si-Ping Ge,Bo Zhen,Ting-Ting Yu,Ling Wang,Hua Wang,Yu Liu,Ye-Shan Chen,Jun-Hua Mei,Xiao-Jia Gao,Zhu-Yan Li,Li-Juan Gan,Can He,Zhen Li,Yu-Ying Shi,Yu-Wen Qi,Jing Yang,Daniel G. Tenen,Daniel G. Tenen,Li Chai,Lorelei A. Mucci,Mauricio Santillana,Mauricio Santillana,Hongbing Cai +40 more
TL;DR: In a study of 105 patients with cancer and 536 without, all with confirmed COVID-19, cancer was predictive of more severe disease, with stage IV cancer, hematologic cancer, and lung cancer being associated with worse outcomes.
Journal ArticleDOI
Plasticity of marrow derived stem cells
TL;DR: Only after a better understanding of the mechanisms involved and of the cells required for this differentiation will the authors be able to fully harness adult stem cell plasticity for clinical purposes.
Journal ArticleDOI
Sall4 modulates embryonic stem cell pluripotency and early embryonic development by the transcriptional regulation of Pou5f1.
Jinqiu Zhang,Wai Leong Tam,Wai Leong Tam,Guo Qing Tong,Qiang Wu,Hsiao-Yun Chan,Boon Seng Soh,Yuefei Lou,Jianchang Yang,Yupo Ma,Li Chai,Huck-Hui Ng,Huck-Hui Ng,Thomas Lufkin,Thomas Lufkin,Paul Robson,Paul Robson,Bing Lim,Bing Lim +18 more
TL;DR: It is demonstrated that Sall4 is a transcriptional activator of Pou5f1 and has a critical role in the maintenance of ES cell pluripotency by modulating Oct4 expression, and indicates that SAll4 is important for early embryonic cell-fate decisions.
Journal ArticleDOI
Oncofetal Gene SALL4 in Aggressive Hepatocellular Carcinoma
Kol Jia Yong,Chong Gao,Joline S.J. Lim,Joline S.J. Lim,Benedict Yan,Henry Yang,Todor Dimitrov,Akira Kawasaki,Chee Wee Ong,Kwong-Fai Wong,Sanghoon Lee,Sharada Ravikumar,Supriya Srivastava,Xi Tian,Ronnie T.P. Poon,Sheung Tat Fan,John M. Luk,John M. Luk,John M. Luk,Yock Young Dan,Manuel Salto-Tellez,Manuel Salto-Tellez,Li Chai,Daniel G. Tenen,Daniel G. Tenen +24 more
TL;DR: The absence of Sall4 expression in the healthy adult liver enhances the potential of SALL4 as a treatment target in hepatocellular carcinoma, and loss-of-function studies confirmed the critical role of Salls4 in cell survival and tumorigenicity.
Journal ArticleDOI
SALL4, a novel oncogene, is constitutively expressed in human acute myeloid leukemia (AML) and induces AML in transgenic mice
Yupo Ma,Wei Cui,Jianchang Yang,Jun Qu,Chunhui Di,Hesham M. Amin,Raymond Lai,Jerome Ritz,Diane S. Krause,Li Chai +9 more
TL;DR: The murine model provides a useful platform to study human MDS/AML transformation, as well as the Wnt/beta-catenin pathway's role in the pathogenesis of leukemia stem cells.