P
Paul Robson
Researcher at University of Connecticut
Publications - 122
Citations - 17780
Paul Robson is an academic researcher from University of Connecticut. The author has contributed to research in topics: Embryonic stem cell & Stem cell. The author has an hindex of 50, co-authored 101 publications receiving 14706 citations. Previous affiliations of Paul Robson include Children's Hospital of Philadelphia & Agency for Science, Technology and Research.
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Journal ArticleDOI
The Oct4 and Nanog transcription network regulates pluripotency in mouse embryonic stem cells.
Yuin-Han Loh,Qiang Wu,Joon Lin Chew,Joon Lin Chew,Vinsensius B. Vega,Weiwei Zhang,Weiwei Zhang,Xi Chen,Xi Chen,Guillaume Bourque,Joshy George,Bernard Leong,Jun Liu,Kee Yew Wong,Ken W. Sung,Charlie W.H. Lee,Xiao Dong Zhao,Kuo Ping Chiu,Leonard Lipovich,Vladimir A. Kuznetsov,Paul Robson,Paul Robson,Lawrence W. Stanton,Chia-Lin Wei,Yijun Ruan,Bing Lim,Bing Lim,Huck-Hui Ng,Huck-Hui Ng +28 more
TL;DR: By integrating RNA interference–mediated depletion of Oct4 and Nanog with microarray expression profiling, it is demonstrated that these factors can activate or suppress transcription, and it is shown that common core downstream targets are important to keep ES cells from differentiating.
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Transcriptional regulation of nanog by OCT4 and SOX2.
David Rodda,Joon-Lin Chew,Joon-Lin Chew,Leng-Hiong Lim,Yuin-Han Loh,Yuin-Han Loh,Bei Wang,Huck-Hui Ng,Huck-Hui Ng,Paul Robson +9 more
TL;DR: By specific knockdown of Oct4 and Sox2 mRNA by RNA interference in embryonic stem cells, this work provides genetic evidence for a link between Oct4, Sox2, and the Nanog promoter, extending the understanding of the pluripotent genetic regulatory network within which the Sox2-Oct4 complex are at the top of the regulatory hierarchy.
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Cross-Species Single-Cell Analysis of Pancreatic Ductal Adenocarcinoma Reveals Antigen-Presenting Cancer-Associated Fibroblasts
Ela Elyada,Ela Elyada,Mohan Bolisetty,Pasquale Laise,William F. Flynn,Elise T. Courtois,Richard A. Burkhart,Jonathan Teinor,Pascal Belleau,Giulia Biffi,Giulia Biffi,Matthew S. Lucito,Matthew S. Lucito,Santhosh Sivajothi,Todd D. Armstrong,Dannielle D. Engle,Dannielle D. Engle,Dannielle D. Engle,Kenneth H. Yu,Yuan Hao,Christopher L. Wolfgang,Young-Kyu Park,Young-Kyu Park,Jonathan B. Preall,Elizabeth M. Jaffee,Andrea Califano,Paul Robson,David A. Tuveson,David A. Tuveson +28 more
TL;DR: A new population of CAFs that express MHC class II and CD74, but do not express classical co-stimulatory molecules are described, and it is found that they activate CD4+ T cells in an antigen-specific fashion in a model system, confirming their putative immune-modulatory capacity.
Journal ArticleDOI
Resolution of Cell Fate Decisions Revealed by Single-Cell Gene Expression Analysis from Zygote to Blastocyst
Guoji Guo,Mikael Huss,Guo Qing Tong,Chaoyang Wang,Li Li Sun,Neil D. Clarke,Paul Robson,Paul Robson +7 more
TL;DR: It is shown that in the morula, blastomeres coexpress transcription factors specific to different lineages, but by the 64-cell stage three cell types can be clearly distinguished according to their quantitative expression profiles.
Journal ArticleDOI
Reference component analysis of single-cell transcriptomes elucidates cellular heterogeneity in human colorectal tumors
Huipeng Li,Elise T. Courtois,Debarka Sengupta,Debarka Sengupta,Yuliana Tan,Kok Hao Chen,Jolene Jie Lin Goh,Say Li Kong,Clarinda Chua,Lim Kiat Hon,Wah Siew Tan,Mark T. C. Wong,Paul Jongjoon Choi,Lawrence J K Wee,Axel M. Hillmer,Iain Beehuat Tan,Iain Beehuat Tan,Paul Robson,Shyam Prabhakar +18 more
TL;DR: The results demonstrate that unbiased single-cell RNA–seq profiling of tumor and matched normal samples provides a unique opportunity to characterize aberrant cell states within a tumor.