L
Li Ma
Researcher at Chinese Academy of Sciences
Publications - 68
Citations - 1512
Li Ma is an academic researcher from Chinese Academy of Sciences. The author has contributed to research in topics: Cavefish & Gene. The author has an hindex of 16, co-authored 63 publications receiving 994 citations. Previous affiliations of Li Ma include Shanghai University & Soochow University (Suzhou).
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Journal ArticleDOI
The cavefish genome reveals candidate genes for eye loss
Suzanne E. McGaugh,Suzanne E. McGaugh,Joshua B. Gross,Bronwen Aken,Maryline Blin,Richard Borowsky,Domitille Chalopin,Hélène Hinaux,William R. Jeffery,Alex C. Keene,Li Ma,Patrick Minx,Daniel N. Murphy,Kelly E. O’Quin,Sylvie Rétaux,Nicolas Rohner,Steve Searle,Bethany A. Stahl,Clifford J. Tabin,Jean Nicolas Volff,Masato Yoshizawa,Wesley C. Warren +21 more
TL;DR: The first de novo genome assembly for Astyanax mexicanus cavefish is presented, contrast repeat elements to other teleost genomes, identify candidate genes underlying quantitative trait loci (QTL), and assay these candidate genes for potential functional and expression differences.
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A Potential Benefit of Albinism in Astyanax Cavefish: Downregulation of the oca2 Gene Increases Tyrosine and Catecholamine Levels as an Alternative to Melanin Synthesis
TL;DR: A key finding is that knockdown of oca2 expression in surface fish embryos delays the development of pigmented melanophores and simultaneously increases L-tyrosine and dopamine, which could be important for adaptation to the challenging cave environment.
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Long noncoding RNA MALAT1 releases epigenetic silencing of HIV-1 replication by displacing the polycomb repressive complex 2 from binding to the LTR promoter.
TL;DR: The data have identified MALAT1 as a promoter of HIV-1 transcription, and suggested that MALatin modulator polycomb repressive complex 2 may be targeted for the development of new therapeutics.
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Iron-dependent histone 3 lysine 9 demethylation controls B cell proliferation and humoral immune responses.
Yuhang Jiang,Yuhang Jiang,Cuifeng Li,Cuifeng Li,Qian Wu,Qian Wu,Qian Wu,Peng An,Peng An,Peng An,Laiquan Huang,Jia Wang,Jia Wang,Jia Wang,Chen Chen,Xi Chen,Xi Chen,Fan Zhang,Fan Zhang,Fan Zhang,Li Ma,Sanhong Liu,Hanqing He,Shuyun Xie,Yangbai Sun,H Liu,H Liu,Yu Zhan,Yu Tao,Zhi Liu,Zhi Liu,Xiaohua Sun,Xiaohua Sun,Yiming Hu,Yiming Hu,Qi Wang,Deji Ye,Jie Zhang,Shanhua Zou,Ying Wang,Gang Wei,Yongzhong Liu,Yufang Shi,Y. Eugene Chin,Yongqiang Hao,Fudi Wang,Fudi Wang,Fudi Wang,Xiaoren Zhang,Xiaoren Zhang +49 more
TL;DR: The authors show an important role for iron in B cell proliferation via histone 3 lysine 9 (H3K9) demethylation at the cyclin E1 promoter and show that iron-deficient individuals have a significantly reduced antibody response to the vaccine when compared to iron-normal controls.
Journal ArticleDOI
Specific Reactivation of Latent HIV-1 by dCas9-SunTag-VP64-mediated Guide RNA Targeting the HIV-1 Promoter
Haiyan Ji,Zhengtao Jiang,Panpan Lu,Li Ma,Chuan Li,Hanyu Pan,Zheng Fu,Xiying Qu,Pengfei Wang,Junxiao Deng,Xinyi Yang,Jian-Hua Wang,Huanzhang Zhu +12 more
TL;DR: The data demonstrated dCas9-SunTag-VP64 system can effectively and specifically reactivate latent HIV-1 transcription, suggesting that this strategy could offer a novel approach to anti-HIV-1 latency.