L
Liangqing Zhang
Researcher at Guangdong Medical College
Publications - 58
Citations - 2703
Liangqing Zhang is an academic researcher from Guangdong Medical College. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 18, co-authored 42 publications receiving 2028 citations. Previous affiliations of Liangqing Zhang include Yunnan University & University of Hong Kong.
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Journal ArticleDOI
Review of the Clinical Characteristics of Coronavirus Disease 2019 (COVID-19)
TL;DR: The purpose of this brief review is to summarize published studies as of late February 2020 on the clinical features, symptoms, complications, and treatments of COVID-19 and help provide guidance for frontline medical staff in the clinical management of this outbreak.
Journal ArticleDOI
ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy
Wenxian Wu,Weili Tian,Zhe Hu,Guo Chen,Lei Huang,Wen Li,Xingli Zhang,Peng Xue,Changqian Zhou,Lei Liu,Yushan Zhu,Xingliang Zhang,Longxuan Li,Liangqing Zhang,Sen-Fang Sui,Bin Zhao,Du Feng +16 more
TL;DR: It is shown that FUNDC1 regulates ULK1 recruitment to damaged mitochondria, where FUNDC 1 phosphorylation by ULK 1 is crucial for mitophagy.
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FUNDC1 regulates mitochondrial dynamics at the ER-mitochondrial contact site under hypoxic conditions
Wenxian Wu,Chunxia Lin,Keng Wu,Lei Jiang,Xiaojing Wang,Wen Li,Haixia Zhuang,Xingliang Zhang,Hao Chen,Shupeng Li,Yue Yang,Yue Lu,Jingjing Wang,Runzhi Zhu,Liangqing Zhang,Sen-Fang Sui,Ning Tan,Bin Zhao,Jingjing Zhang,Longxuan Li,Du Feng,Du Feng +21 more
TL;DR: FUNDC1 integrates mitochondrial fission and mitophagy at the interface of the MAM by working in concert with DRP1 and calnexin under hypoxic conditions in mammalian cells.
Journal ArticleDOI
Phosphorylation of ULK1 by AMPK regulates translocation of ULK1 to mitochondria and mitophagy
Weili Tian,Wen Li,Yinqin Chen,Ze-Ming Yan,Xia Huang,Haixia Zhuang,Wangtao Zhong,Yusen Chen,Wenxian Wu,Chunxia Lin,Hao Chen,Xiaoyan Hou,Liangqing Zhang,Sen-Fang Sui,Bin Zhao,Zhe Hu,Longxuan Li,Du Feng +17 more
TL;DR: It is found that hypoxia induces phosphorylation of ULK1 at Serine‐555 by Adenosine 5′‐monophosphate (AMP)‐activated protein kinase (AMPK), which is critical for translocation ofULK1 to mitochondria and for mitophagy in response to hypoxic stress.
Journal ArticleDOI
MicroRNA-137 Is a Novel Hypoxia-responsive MicroRNA That Inhibits Mitophagy via Regulation of Two Mitophagy Receptors FUNDC1 and NIX
Wen Li,Xingli Zhang,Haixia Zhuang,He-ge Chen,Yinqin Chen,Weili Tian,Wenxian Wu,Ying Li,Sijie Wang,Liangqing Zhang,Yusen Chen,Longxuan Li,Bin Zhao,Sen-Fang Sui,Zhe Hu,Du Feng +15 more
TL;DR: It is demonstrated that a novel hypoxia-responsive microRNA, microRNA-137 (miR-137), markedly inhibits mitochondrial degradation by Autophagy without affecting global autophagy.