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Guo Chen
Researcher at Nankai University
Publications - 28
Citations - 3194
Guo Chen is an academic researcher from Nankai University. The author has contributed to research in topics: Mitophagy & Autophagy. The author has an hindex of 15, co-authored 22 publications receiving 2214 citations. Previous affiliations of Guo Chen include French Institute of Health and Medical Research.
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Journal ArticleDOI
Mitochondrial outer-membrane protein FUNDC1 mediates hypoxia-induced mitophagy in mammalian cells
Lei Liu,Du Feng,Guo Chen,Ming Chen,Qiaoxia Zheng,Pingping Song,Qi Ma,Chongzhuo Zhu,Rui Wang,Wanjun Qi,Lei Huang,Peng Xue,Baowei Li,Xiaohui Wang,Haijing Jin,Jun Wang,Fuquan Yang,Pingsheng Liu,Yushan Zhu,Sen-Fang Sui,Quan Chen,Quan Chen +21 more
TL;DR: It is reported that FUNDC1, an integral mitochondrial outer-membrane protein, is a receptor for hypoxia-induced mitophagy, and its findings offer insights into mitochondrial quality control in mammalian cells.
Journal ArticleDOI
A Regulatory Signaling Loop Comprising the PGAM5 Phosphatase and CK2 Controls Receptor-Mediated Mitophagy
Guo Chen,Zhe Han,Du Feng,Yanfang Chen,Linbo Chen,Hao Wu,Li Huang,Changqian Zhou,Xiangyu Cai,Changying Fu,Liangwei Duan,Xiaohui Wang,Lei Liu,Xinqi Liu,Yuequan Shen,Yushan Zhu,Quan Chen,Quan Chen +17 more
TL;DR: The results reveal a mechanistic signaling pathway linking mitochondria-damaging signals to the dephosphorylation of FUNDC1 by PGAM5, which ultimately induces mitophagy.
Journal ArticleDOI
ULK1 translocates to mitochondria and phosphorylates FUNDC1 to regulate mitophagy
Wenxian Wu,Weili Tian,Zhe Hu,Guo Chen,Lei Huang,Wen Li,Xingli Zhang,Peng Xue,Changqian Zhou,Lei Liu,Yushan Zhu,Xingliang Zhang,Longxuan Li,Liangqing Zhang,Sen-Fang Sui,Bin Zhao,Du Feng +16 more
TL;DR: It is shown that FUNDC1 regulates ULK1 recruitment to damaged mitochondria, where FUNDC 1 phosphorylation by ULK 1 is crucial for mitophagy.
Journal ArticleDOI
Mitophagy, Mitochondrial Homeostasis, and Cell Fate.
TL;DR: Recent findings on molecular pathways governing mitophagy and its coordination with other mitochondrial behaviors, which together determine cellular fate are summarized.
Journal ArticleDOI
Mitophagy: An Emerging Role in Aging and Age-Associated Diseases.
TL;DR: There is increasing evidence that mitophagy is significantly impaired in several human pathologies including aging and age-related diseases such as neurodegenerative disorders, cardiovascular pathologies and cancer and therapeutic interventions aiming at the induction of mitophile may have the potency to ameliorate these dysfunctions.