Siqian He

TL;DR: An overview of the PubChem Substance and Compound databases is provided, including data sources and contents, data organization, data submission using PubChem Upload, chemical structure standardization, web-based interfaces for textual and non-textual searches, and programmatic access.

TL;DR: This paper describes the new developments in PubChem, a key chemical information resource for the biomedical research community, which released new web interfaces, such as PubChem Target View page, Sources page, Bioactivity dyad pages and Patent View page.

TL;DR: In the past two years, PubChem made substantial improvements, including a data model change for the data objects used by these pages as well as by programmatic users, and several new services were introduced.

TL;DR: The progress of the curation effort and associated improvements in the functionality of the CDD information retrieval system are reported on.

TL;DR: NCBI's Conserved Domain Database is a collection of multiple sequence alignments and derived database search models, which represent protein domains conserved in molecular evolution, and provides annotation of domain footprints and conserved functional sites on protein sequences.