Fu Lu

TL;DR: NCBI's CDD, the Conserved Domain Database, enters its 15th year as a public resource for the annotation of proteins with the location of conserved domain footprints and aims at increasing coverage and providing finer-grained classifications of common protein domains.

TL;DR: NCBI's Conserved Domain Database (CDD) aims at annotating biomolecular sequences with the location of evolutionarily conserved protein domain footprints, and functional sites inferred from such footprints.

TL;DR: The progress of the curation effort and associated improvements in the functionality of the CDD information retrieval system are reported on.

TL;DR: To this date, the majority of protein 3D structures are represented by models tracked by CDD, and CDD curators are characterizing novel families that emerge from protein structure determination efforts.

TL;DR: A novel helper application, CDTree, is presented, which enables users of the CDD resource to examine curated hierarchies and serve as a powerful tool in protein classification, as they allow users to analyze protein sequences in the context of domain family hierarchies.