Lichen Yin

TL;DR: A synergistic anti-cancer efficacy between DOX-mediated chemotherapy and Ce6-mediated photodynamic therapy (PDT) was achieved, resulting in reduced side effects to normal tissues/cells, and it renders promising applications for the programmed combination of chemotherapy and PDT toward cancer treatment.

TL;DR: The recent progress in the group on the synthesis of functional PAHAs via ROP of OCAs and their self-assembly and biomedical applications is highlighted and new synthetic methodologies that allow the facile preparation ofPAHAs with controlled molecular weights and various functionalities through ROPOf OCAs are reviewed and evaluated.

TL;DR: Compared to conventional small-molecule contrast agents, poly(iohexol) nanoparticles exhibited substantially protracted retention within the tumor bed and a 36-fold increase in CT contrast 4 h post injection, which makes it possible to acquire CT images with improved diagnosis accuracy over a broad time frame without multiple administrations.

TL;DR: An NIR-light-triggered CO release system based on mesoporous Prussian blue nanoparticles was developed to reverse MDR via CO-induced metabolic exhaustion, the first time MDR has been overcome using a CO delivery system.

TL;DR: This study reports the design of a new series of cationic, α-helical polypeptides with different side charged groups (amine and guanidine) and hydrophobicity, and mechanistically unraveled the effect ofpolypeptide structure on the gene delivery capability.