L
Lillian Cruz-Orengo
Researcher at University of California, Davis
Publications - 20
Citations - 1073
Lillian Cruz-Orengo is an academic researcher from University of California, Davis. The author has contributed to research in topics: Experimental autoimmune encephalomyelitis & Spinal cord injury. The author has an hindex of 12, co-authored 20 publications receiving 941 citations. Previous affiliations of Lillian Cruz-Orengo include University of Puerto Rico & Washington University in St. Louis.
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Journal ArticleDOI
CXCR7 influences leukocyte entry into the CNS parenchyma by controlling abluminal CXCL12 abundance during autoimmunity
Lillian Cruz-Orengo,David W. Holman,Denise A. Dorsey,Liang Zhou,Penglie Zhang,Melissa Wright,Erin E. McCandless,Jigisha R. Patel,Gary D. Luker,Dan R. Littman,John H. Russell,Robyn S. Klein +11 more
TL;DR: During CNS autoimmunity, brain endothelial cell CXCR7 internalizes CXCL12 from the perivascular space, thereby permitting leukocyte migration into the CNS parenchyma.
Journal ArticleDOI
Viral Pathogen-Associated Molecular Patterns Regulate Blood-Brain Barrier Integrity via Competing Innate Cytokine Signals
Brian P. Daniels,David W. Holman,Lillian Cruz-Orengo,Harsha Jujjavarapu,Douglas M. Durrant,Robyn S. Klein +5 more
TL;DR: This study shows that detection of WNV by host tissues induces innate immune cytokine expression at the BBB, regulating BBB structure and function and impacting transendothelial trafficking of W NV, providing new understanding of host-pathogen interactions at theBBB during viral encephalitis.
Journal ArticleDOI
Cutaneous Nociception Evoked by 15-delta PGJ2 via Activation of Ion Channel TRPA1
Lillian Cruz-Orengo,Ajay Dhaka,Robert J. Heuermann,Timothy J Young,Michael C. Montana,Eric J. Cavanaugh,Donghee Kim,Gina M. Story +7 more
TL;DR: It is shown that 15d-PGJ2 induces acute nociception when administered cutaneously and does so via a TRPA1-specific mechanism.
Journal ArticleDOI
Upregulation of EphA receptor expression in the injured adult rat spinal cord.
Christopher A. Willson,Margarita Irizarry-Ramírez,Hope E. Gaskins,Lillian Cruz-Orengo,Johnny D. Figueroa,Scott R. Whittemore,Jorge D. Miranda +6 more
TL;DR: Using semiquantitative RT-PCR to investigate mRNA expression after SCI, it is found that EphA3, A4, and A7 mRNAs were upregulated.
Journal ArticleDOI
Enhanced sphingosine-1-phosphate receptor 2 expression underlies female CNS autoimmunity susceptibility
Lillian Cruz-Orengo,Brian P. Daniels,Denise A. Dorsey,Sarah Alison Basak,Jose G. Grajales-Reyes,Erin E. McCandless,Laura Piccio,Robert E. Schmidt,Anne H. Cross,Seth D. Crosby,Robyn S. Klein +10 more
TL;DR: This work has identified sphingosine-1-phosphate receptor 2 (S1PR2) as a sex- and strain-specific, disease-modifying molecule that regulates BBB permeability by destabilizing adherens junctions and implicate S1 PR2 in sex-specific patterns of disease during CNS autoimmunity.