Robert E. Schmidt

TL;DR: The fact that sympathetic neurons must synthesize protein and RNA to die when deprived of NGF indicates that NGF, and presumably other neurotrophic factors, maintains neuronal survival by suppressing an endogenous, active death program.

TL;DR: It is demonstrated that PGC-1α is necessary for appropriate adaptation to the metabolic and physiologic stressors of postnatal life.

TL;DR: The demonstration of ISG15 as a novel antiviral molecule with activity against both RNA and DNA viruses provides a target for the development of therapies against important human pathogens.

TL;DR: It is shown that viral infection of adult hippocampal neurons induces complement-mediated elimination of presynaptic terminals in a murine WNV neuroinvasive disease model, which provides a new murine model of WNV-induced spatial memory impairment, and identifies a potential mechanism underlying neurocognitive impairment in patients recovering from WNV Neuroinvasive Disease.

TL;DR: In this article, the authors explore the mechanism by which mutations in the mitochondrial fusion protein mitofusin 2 (MFN2) lead to neuropathy and explore how MFN2 mutations lead to degeneration of peripheral axons.