Lin Cui

TL;DR: The characteristics MVs possess that enable them to participate in mineral deposition are reviewed, the content of skeletal tissue- and soft tissue-derived MVs are outlined, and their key mineralisation mediators that could be targeted for future therapeutic use are discussed.

TL;DR: Immunohistochemistry and mitochondrial function assessment suggest that OCN plays a crucial role in arterial calcification mediated by Wnt/β‐catenin signaling through reduced maximal respiration and Mitochondrial dynamics may represent a novel therapeutic target for clinical intervention.

TL;DR: Calcium is identified as a key driver of aortic valve calcification, which may directly underpin the increased susceptibility of ESRD patients to accelerated development of CAVD.

TL;DR: Fluorescein-BP is therefore a highly sensitive and specific imaging probe for the detection of vascular calcification, with the potential to improve not only ex vivo assessments of HAP deposition but also the Detection of vascular microcalcification in humans.

TL;DR: The present study demonstrated that the use of immortalised sheep and rat VIC cell lines is a convenient and cost effective system to investigate CAVD in vitro, and will make a useful contribution to increasing current understanding of the pathophysiological process.