Andrew H. Baker

TL;DR: It is shown that FX binds to the Ad5 hexon, not fiber, via an interaction between the FX Gla domain and hypervariable regions of the hexon surface, which reveals an unanticipated function for hexon in mediating liver gene transfer in vivo.

TL;DR: The newly discovered UMOD locus for hypertension has the potential to give new insights into the role of uromodulin in BP regulation and to identify novel drugable targets for reducing cardiovascular risk.

TL;DR: A framework for its systematic advancement at the molecular and translational levels is proposed and a number of challenges are reviewed, including the lack of a precise functional and molecular definition, lack of understanding of the causative pathological role of EndMT in CVDs, and a lack of robust human data corroborating the extent and causality.

TL;DR: In this article, the role of miR-145 in pulmonary arterial hypertension (PAH) was evaluated in mice treated with anti-miRs via measurement of systolic right ventricular pressure, right ventriches hypertrophy, and percentage of remodeled pulmonary arteries.

TL;DR: MiR-143-3p modulated both cellular and exosome-mediated responses in pulmonary vascular cells, whereas inhibition of miR- 143- 3p blocked experimental pulmonary hypertension, and these findings confirm an important role for the miR/145 cluster in PAH pathobiology.