L
Lina Bezdetnaya
Researcher at University of Lorraine
Publications - 127
Citations - 4212
Lina Bezdetnaya is an academic researcher from University of Lorraine. The author has contributed to research in topics: Photodynamic therapy & Temoporfin. The author has an hindex of 33, co-authored 119 publications receiving 3682 citations. Previous affiliations of Lina Bezdetnaya include Centre national de la recherche scientifique & Nancy-Université.
Papers
More filters
Journal ArticleDOI
Fluorescence detection of bladder cancer: a review.
TL;DR: Endo- and exogenous fluorescence for early diagnosis of in situ carcinoma of the bladder, with a particular emphasis on the 5-aminolevulinic acid, its ester derivative (h-ALA) and hypericin, demonstrated an excellent sensitivity above 90% and specificity ranging from 70% to 90%.
Journal ArticleDOI
Anticancer Drug Delivery: An Update on Clinically Applied Nanotherapeutics
Sophie Marchal,Sophie Marchal,Amélie El Hor,Marie Millard,Marie Millard,Véronique Gillon,Lina Bezdetnaya,Lina Bezdetnaya +7 more
TL;DR: Evaluated the extent of nanotherapeutics used in oncology by providing an insight into the most successful concepts and the reasons that prevent nanodrugs from expanding to clinic are discussed, and the efforts that must be taken to take full advantage of the great potential of nanomedicine are highlighted.
Journal ArticleDOI
Drug delivery to solid tumors: the predictive value of the multicellular tumor spheroid model for nanomedicine screening
Marie Millard,Ilya Yakavets,Vladimir Zorin,Aigul Kulmukhamedova,Sophie Marchal,Lina Bezdetnaya +5 more
TL;DR: This review presents recent developments in MCTS models for a better comprehension of the interactions between NPs and tumor components that affect tumor drug delivery, particularly suitable for the high-throughput screening of new nanodrugs.
Journal ArticleDOI
NIR fluorescence-guided tumor surgery: new strategies for the use of indocyanine green
TL;DR: This review article focuses on recent developments in ICG complexation strategies to improve near-infrared fluorescence-guided tumor surgery, describing targeted and nontargeted ICG nanoparticle models and ICGcomplexation with targeting agents.
Journal ArticleDOI
Effects of fluence rate on cell survival and photobleaching in meta-tetra-(hydroxyphenyl)chlorin-photosensitized Colo 26 multicell tumor spheroids.
Stéphanie Coutier,Soumya Mitra,Lina Bezdetnaya,Robert Michel Parache,Irene Georgakoudi,Thomas H. Foster,François Guillemin +6 more
TL;DR: It is concluded that the fluence rate dependence of the cell survival and of mTHPC photobleaching is due to photochemical oxygen consumption and a predominantly singlet oxygen-mediated mechanism of mTetra-(hydroxyphenyl)chlorin photOBleaching.