L
Lina Bezdetnaya
Researcher at University of Lorraine
Publications - 127
Citations - 4212
Lina Bezdetnaya is an academic researcher from University of Lorraine. The author has contributed to research in topics: Photodynamic therapy & Temoporfin. The author has an hindex of 33, co-authored 119 publications receiving 3682 citations. Previous affiliations of Lina Bezdetnaya include Centre national de la recherche scientifique & Nancy-Université.
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Journal ArticleDOI
Fluorescence imaging of Foscan and Foslip in the plasma membrane and in whole cells.
Henri-Pierre Lassalle,Michael Wagner,Lina Bezdetnaya,François Guillemin,Herbert Schneckenburger +4 more
TL;DR: Selective measurements within or in close proximity to the plasma membrane indicate that Foscan and Foslip are taken up by the cells in a similar way, but may be located in different cellular sites after an incubation time of 24 h.
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Temoporfin-in-Cyclodextrin-in-Liposome-A New Approach for Anticancer Drug Delivery: The Optimization of Composition.
Ilya Yakavets,Ilya Yakavets,Henri-Pierre Lassalle,Dietrich Scheglmann,Arno Wiehe,Vladimir Zorin,Vladimir Zorin,Lina Bezdetnaya +7 more
TL;DR: Among all tested DCLs, trimethyl-β-CD-based DCL demonstrated a homogenous accumulation of mTHPC across tumor spheroid volume, thus supposing optimal mTH PC distribution.
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Inclusion complexation with β-cyclodextrin derivatives alters photodynamic activity and biodistribution of meta-tetra(hydroxyphenyl)chlorin.
Igor Yankovsky,Estelle Bastien,Ilya Yakavets,Ivan I. Khludeyev,Henri-Pierre Lassalle,Susanna Gräfe,Lina Bezdetnaya,Vladimir Zorin +7 more
TL;DR: In vivo study confirms the fact that the use of β-CDs allows to modify mTHPC distribution processes in tumor bearing animals that is reflected in the decreased level of PS accumulation in skin and muscles, as well as in the increasedPS accumulation in tumor.
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Biosynthesis and photodynamic efficacy of protoporphyrin IX (PpIX) generated by 5-aminolevulinic acid (ALA) or its hexylester (hALA) in rat bladder carcinoma cells.
TL;DR: The present study addresses the ALA and hALA-induced PpIX pharmacokinetic profile using rat bladder carcinoma cells (AY27) and points out to enzyme saturation in the biosynthetic pathway or/and the constitution of ALA reserve.
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Photodynamic Properties of Meta-Tetra(hydroxyphenyl)chlorin in Human Tumor Cells
TL;DR: It is suggested that mTHPC photosensitizes cell killing predominantly by type II, singlet oxygen-mediated photodynamic reactions, suggesting that reactions of lipid peroxidation play only a minor role in the overall photocytotoxic effect of m THPC.