L
Lina Bezdetnaya
Researcher at University of Lorraine
Publications - 127
Citations - 4212
Lina Bezdetnaya is an academic researcher from University of Lorraine. The author has contributed to research in topics: Photodynamic therapy & Temoporfin. The author has an hindex of 33, co-authored 119 publications receiving 3682 citations. Previous affiliations of Lina Bezdetnaya include Centre national de la recherche scientifique & Nancy-Université.
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Journal ArticleDOI
mTHPC-loaded extracellular vesicles outperform liposomal and free mTHPC formulations by an increased stability, drug delivery efficiency and cytotoxic effect in tridimensional model of tumors
Marie Millard,Ilya Yakavets,Max Piffoux,Amanda Brun,Florence Gazeau,Jean-Michel Guigner,Jordane Jasniewski,Henri-Pierre Lassalle,Claire Wilhelm,Lina Bezdetnaya +9 more
TL;DR: The obtained results demonstrate that EVs should be considered as perspective nanocarriers for mTHPC-mediated PDT, and are considered to be an attractive option to deliver therapeutic molecules into cancer cells.
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Primary photodamage sites and mitochondrial events after Foscan photosensitization of MCF-7 human breast cancer cells.
TL;DR: Although mitochondria are not directly affected by the treatment, they can be strongly implicated in Foscan®-mediated MCF-7 cell death by late and indirect mechanism.
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Photodynamic therapy with intratumoral administration of Lipid-Based mTHPC in a model of breast cancer recurrence
Marie Ange d'Hallewin,Dmitri Kochetkov,Dmitri Kochetkov,Yan Viry-Babel,Agnès Leroux,Elisabethe Werkmeister,Dominique Dumas,Susanna Gräfe,Vladimir Zorin,François Guillemin,Lina Bezdetnaya +10 more
TL;DR: The potential use of an intratumoral injection of a liposomal formulation of mTHPC (Foslip) in a mouse model of local recurrence of breast cancer is evaluated.
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PAMAM G4.5-chlorin e6 dendrimeric nanoparticles for enhanced photodynamic effects
Estelle Bastien,Estelle Bastien,Raphaël Schneider,Steffen Hackbarth,Dominique Dumas,Jordane Jasniewski,Beate Röder,Lina Bezdetnaya,Lina Bezdetnaya,Henri-Pierre Lassalle,Henri-Pierre Lassalle +10 more
TL;DR: It is demonstrated that PEGylated G4.5 PAMAM-Ce6 dendrimers may offer effective biocompatible nanoparticles for improved photodynamic treatment in a preclinical tumor model.
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Kinetics, biodistribution and therapeutic efficacy of hexylester 5-aminolevulinate induced photodynamic therapy in an orthotopic rat bladder tumor model
TL;DR: While different hALA concentrations ind uce identical PpIX fluorescence intensities, the PDT outcome was considerably different, suggesting that fluorescence does not necessarily predict the therapeutic efficacy of PDT.