L
Lina Bezdetnaya
Researcher at University of Lorraine
Publications - 127
Citations - 4212
Lina Bezdetnaya is an academic researcher from University of Lorraine. The author has contributed to research in topics: Photodynamic therapy & Temoporfin. The author has an hindex of 33, co-authored 119 publications receiving 3682 citations. Previous affiliations of Lina Bezdetnaya include Centre national de la recherche scientifique & Nancy-Université.
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Journal ArticleDOI
Stroma-rich co-culture multicellular tumor spheroids as a tool for photoactive drugs screening
Ilya Yakavets,Ilya Yakavets,Samuel Jenard,Aurélie François,Yulia Maklygina,Yulia Maklygina,Victor B. Loschenov,Victor B. Loschenov,Henri-Pierre Lassalle,Gilles Dolivet,Lina Bezdetnaya +10 more
TL;DR: A 3D stroma-rich in vitro model of HNSCC is constructed, using cancer-associated MeWo skin fibroblasts and FaDu pharynx squamous cell carcinoma, and it is demonstrated that the presence of stroma influences the behavior of photoactive drugs in different ways.
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The alteration of temoporfin distribution in multicellular tumor spheroids by β-cyclodextrins.
Ilya Yakavets,Igor Yankovsky,Marie Millard,Laureline Lamy,Henri-Pierre Lassalle,Arno Wiehe,Vladimir Zorin,Lina Bezdetnaya +7 more
TL;DR: To be effective anticancer drugs must penetrate tissue efficiently, reaching all target population of cancer cells in a concentration sufficient to exert a therapeutic effect, varying the type of β-CD can finely tune the possibility of using mTHPC for diagnostic (delimitation of tumor margins) or therapeutic purposes.
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Parameters Affecting Photodynamic Activity of Foscan® or Meta-tetra(hydroxyphenyl)chlorin (mTHPC) In Vitro and In Vivo
TL;DR: In vitro photodynamic activity of Foscan or meta-tetra(hydroxyphenyl)chlorin (mTHPC) was approximately five times lower in the presence of protein in comparison with serum-free medium, while in vivo the activity was elevated by macroscopic measurement of the necrosis depth after tumoral resection using an in vivo staining procedure with Evans blue dye.
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Meta-tetra(hydroxyphenyl)chlorin-sensitized photodynamic damage of cultured tumor and normal cells in the presence of high concentrations of α-tocopherol
Vladislava O. Melnikova,Lina Bezdetnaya,Irina Belitchenko,Alexander Ya. Potapenko,Jean-Louis Merlin,François Guillemin +5 more
TL;DR: In this study alpha-tocopherol was successfully incorporated by cultured HT29 adenocarcinoma cells, but not by MRC-5 normal fibroblasts, indicating that lipid peroxidation is of minor importance in mTHPC photoactivity.
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Targeted photodynamic therapy in head and neck squamous cell carcinoma: heading into the future
Sophie Marchal,Sophie Marchal,Gilles Dolivet,Gilles Dolivet,Henri-Pierre Lassalle,Henri-Pierre Lassalle,François Guillemin,François Guillemin,Lina Bezdetnaya,Lina Bezdetnaya +9 more
TL;DR: An insight into the future of photodynamic therapy (PDT) in head and neck squamous cell carcinoma (HNSCC) is given through the combination of a photosensitizing agent with light and oxygen, leading to selective tumor eradication.