L
Lina Schiffer
Researcher at University of Birmingham
Publications - 31
Citations - 749
Lina Schiffer is an academic researcher from University of Birmingham. The author has contributed to research in topics: Androgen & Medicine. The author has an hindex of 11, co-authored 23 publications receiving 461 citations. Previous affiliations of Lina Schiffer include Saarland University.
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Journal ArticleDOI
Human steroid biosynthesis, metabolism and excretion are differentially reflected by serum and urine steroid metabolomes: A comprehensive review.
Lina Schiffer,Lise Barnard,Elizabeth S. Baranowski,Lorna C Gilligan,Angela E Taylor,Wiebke Arlt,Cedric H.L. Shackleton,Karl-Heinz Storbeck,Karl-Heinz Storbeck +8 more
TL;DR: In this article, an overview of steroid hormone biosynthesis and metabolism by the liver and peripheral tissues is presented, specifically highlighting the pathways linking and differentiating the serum and urine steroid metabolomes.
Journal ArticleDOI
Intracrine androgen biosynthesis, metabolism and action revisited.
TL;DR: An overview of human C19 steroid biosynthesis including the production of 11-oxygenated androgens, their transport in circulation and uptake into peripheral tissues, and the mechanisms of intracrinology are conceptualised and reviewed.
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MECHANISMS IN ENDOCRINOLOGY: The sexually dimorphic role of androgens in human metabolic disease
TL;DR: It is hypothesised that serum androgen concentrations observed in female androgen excess and male hypogonadism are metabolically disadvantageous, promoting adipose and liver lipid accumulation, central fat mass expansion and insulin resistance.
Journal ArticleDOI
Steroid Metabolome Analysis in Disorders of Adrenal Steroid Biosynthesis and Metabolism.
Karl-Heinz Storbeck,Karl-Heinz Storbeck,Lina Schiffer,Elizabeth S. Baranowski,Elizabeth S. Baranowski,Elizabeth S. Baranowski,Vasileios Chortis,Vasileios Chortis,Vasileios Chortis,Alessandro Prete,Alessandro Prete,Alessandro Prete,Lise Barnard,Lorna C Gilligan,Angela E Taylor,Jan Idkowiak,Jan Idkowiak,Jan Idkowiak,Wiebke Arlt,Cedric H. L. Shackleton,Cedric H. L. Shackleton +20 more
TL;DR: A comprehensive up-to-date overview of the utility of steroid metabolome analysis for the diagnosis and management of inborn disorders of steroidogenesis and autonomous adrenal steroid excess in the context of adrenal tumors is provided.
Journal ArticleDOI
The CYP11B subfamily.
TL;DR: The occurrence and development of P450-catalyzed enzymes in different species, their contribution to the biosynthesis of steroid hormones as well as their regulation at different levels (gene expression, cellular regulation, regulation on the level of proteins) is the topic of this chapter.