L
Linda G. Baum
Researcher at University of California, Los Angeles
Publications - 110
Citations - 14167
Linda G. Baum is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: T cell & Galectin. The author has an hindex of 61, co-authored 110 publications receiving 13383 citations. Previous affiliations of Linda G. Baum include University of California & Sanford-Burnham Institute for Medical Research.
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Journal ArticleDOI
Apoptosis of T cells mediated by galectin-1
TL;DR: Galectin-1 induced apoptosis of activated human T cells and human T leukaemia cell lines and represents a new mechanism for regulating the immune response.
Journal ArticleDOI
Molecular Basis for the Generation in Pigs of Influenza A Viruses with Pandemic Potential
Toshihiro Ito,J. Nelson S. S. Couceiro,Sørge Kelm,Linda G. Baum,Scott Krauss,Maria R. Castrucci,Isabella Donatelli,Hiroshi Kida,James C. Paulson,Robert G. Webster,Robert G. Webster,Yoshihiro Kawaoka,Yoshihiro Kawaoka +12 more
TL;DR: A structural basis for the hypothesis that pigs may serve as “mixing vessels” for the generation of human-avian influenza A virus reassortants, similar to those responsible for the 1957 and 1968 pandemics is demonstrated.
Journal ArticleDOI
Galectins: versatile modulators of cell adhesion, cell proliferation, and cell death
TL;DR: The way in which the modulation of galectin activity may affect strategies for treatment of a variety of human diseases, including autoimmunity and cancer is discussed.
Journal ArticleDOI
Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death.
Marta A. Toscano,Germán A Bianco,Germán A Bianco,Juan M. Ilarregui,Juan M. Ilarregui,Diego O. Croci,Diego O. Croci,Jorge Correale,Joseph D. Hernandez,Norberto Walter Zwirner,Norberto Walter Zwirner,Françoise Poirier,Eleanor M. Riley,Linda G. Baum,Gabriel A. Rabinovich,Gabriel A. Rabinovich +15 more
TL;DR: This work shows that stimuli promoting T helper type 1, TH2 or interleukin 17–producing T helper (TH-17) differentiation can differentially regulate the glycosylation pattern of T helper cells and modulate their susceptibility to galectin-1, a glycan-binding protein with anti-inflammatory activity.
Journal ArticleDOI
Galectins and their ligands: amplifiers, silencers or tuners of the inflammatory response?
Gabriel A. Rabinovich,Linda G. Baum,Nicola Tinari,Roberto Paganelli,Clara Natoli,Fu-Tong Liu,Stefano Iacobelli +6 more
TL;DR: The current wealth of new information promises a future scenario in which individual members of the galectin family or their ligands will be used as powerful anti-inflammatory mediators and selective modulators of the immune response.