J
Joseph D. Hernandez
Researcher at Stanford University
Publications - 23
Citations - 2460
Joseph D. Hernandez is an academic researcher from Stanford University. The author has contributed to research in topics: T cell & Galectin. The author has an hindex of 16, co-authored 21 publications receiving 2075 citations. Previous affiliations of Joseph D. Hernandez include UCLA Medical Center & University of California, Los Angeles.
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Journal ArticleDOI
Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death.
Marta A. Toscano,Germán A Bianco,Germán A Bianco,Juan M. Ilarregui,Juan M. Ilarregui,Diego O. Croci,Diego O. Croci,Jorge Correale,Joseph D. Hernandez,Norberto Walter Zwirner,Norberto Walter Zwirner,Françoise Poirier,Eleanor M. Riley,Linda G. Baum,Gabriel A. Rabinovich,Gabriel A. Rabinovich +15 more
TL;DR: This work shows that stimuli promoting T helper type 1, TH2 or interleukin 17–producing T helper (TH-17) differentiation can differentially regulate the glycosylation pattern of T helper cells and modulate their susceptibility to galectin-1, a glycan-binding protein with anti-inflammatory activity.
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The pathophysiology of anaphylaxis
TL;DR: Current understanding of the immunopathogenesis and pathophysiology of anaphylaxis is described, focusing on the roles of IgE and IgG antibodies, immune effector cells, and mediators thought to contribute to examples of the disorder.
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Different activation signals induce distinct mast cell degranulation strategies
Nicolas Gaudenzio,Riccardo Sibilano,Thomas Marichal,Philipp Starkl,Laurent L. Reber,Nicolas Cenac,Benjamin D. McNeil,Xinzhong Dong,Joseph D. Hernandez,Ronit Sagi-Eisenberg,Ilan Hammel,Axel Roers,Salvatore Valitutti,Mindy Tsai,Eric Espinosa,Stephen J. Galli +15 more
TL;DR: These findings show that cytoplasmic granule secretion from MCs that occurs in response to different activating stimuli can exhibit distinct dynamics and features that are associated with distinct patterns of MC-dependent inflammation.
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Ah, sweet mystery of death! Galectins and control of cell fate.
TL;DR: Understanding how galectins regulate cell viability and function will broaden the knowledge of the roles of galectin in basic biological processes and facilitate development of therapeutic applications for galECTins in autoimmunity, transplant-related disease, and cancer.
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Molecular and cellular mechanisms of food allergy and food tolerance
TL;DR: Roles for the commensal microbiome in promoting oral tolerance and the association of intestinal dysbiosis with food allergy are discussed and growing evidence supports cutaneous sensitization to food antigens as one possible mechanism leading to the failure to develop or loss of oral tolerance.