M
Marta A. Toscano
Researcher at Instituto de Biología y Medicina Experimental
Publications - 55
Citations - 6296
Marta A. Toscano is an academic researcher from Instituto de Biología y Medicina Experimental. The author has contributed to research in topics: Galectin & Galectin-1. The author has an hindex of 28, co-authored 54 publications receiving 5690 citations. Previous affiliations of Marta A. Toscano include University of Buenos Aires & National Scientific and Technical Research Council.
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Journal ArticleDOI
Turning 'sweet' on immunity: galectin-glycan interactions in immune tolerance and inflammation.
TL;DR: An improved understanding of the mechanisms underlying galectins' functions will provide further opportunities for developing new therapies based on the immunoregulatory properties of this multifaceted protein family.
Journal ArticleDOI
Differential glycosylation of TH1, TH2 and TH-17 effector cells selectively regulates susceptibility to cell death.
Marta A. Toscano,Germán A Bianco,Germán A Bianco,Juan M. Ilarregui,Juan M. Ilarregui,Diego O. Croci,Diego O. Croci,Jorge Correale,Joseph D. Hernandez,Norberto Walter Zwirner,Norberto Walter Zwirner,Françoise Poirier,Eleanor M. Riley,Linda G. Baum,Gabriel A. Rabinovich,Gabriel A. Rabinovich +15 more
TL;DR: This work shows that stimuli promoting T helper type 1, TH2 or interleukin 17–producing T helper (TH-17) differentiation can differentially regulate the glycosylation pattern of T helper cells and modulate their susceptibility to galectin-1, a glycan-binding protein with anti-inflammatory activity.
Journal ArticleDOI
Targeted inhibition of galectin-1 gene expression in tumor cells results in heightened T cell-mediated rejection; A potential mechanism of tumor-immune privilege.
Natalia Rubinstein,Mariano J. Alvarez,Norberto Walter Zwirner,Marta A. Toscano,Juan M. Ilarregui,Alicia I. Bravo,Jose Mordoh,Leonardo Fainboim,Osvaldo L. Podhajcer,Gabriel A. Rabinovich +9 more
TL;DR: In this article, the authors demonstrate that Galectin-1 signaling in activated T cells constitutes an important mechanism of tumor-immune escape and that blockade of this inhibitory signal can allow for and potentiate effective immune responses against tumor cells, with profound implications for cancer immunotherapy.
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A pivotal role for galectin-1 in fetomaternal tolerance
Sandra M. Blois,Juan M. Ilarregui,Mareike Tometten,Mariana Garcia,Arif S. Orsal,Rosalia Cordo-Russo,Marta A. Toscano,Germán A Bianco,Peter Kobelt,Bori Handjiski,Irene Tirado,Irene Tirado,Udo R. Markert,Burghard F. Klapp,Françoise Poirier,Julia Szekeres-Bartho,Gabriel A. Rabinovich,Gabriel A. Rabinovich,Petra C. Arck +18 more
TL;DR: It is shown that galectin-1 (Gal-1), an immunoregulatory glycan-binding protein, has a pivotal role in conferring fetomaternal tolerance and is a pivotal regulator of fetom maternal tolerance that has potential therapeutic implications in threatened pregnancies.
Journal ArticleDOI
Tolerogenic signals delivered by dendritic cells to T cells through a galectin-1-driven immunoregulatory circuit involving interleukin 27 and interleukin 10
Juan M. Ilarregui,Diego O. Croci,Diego O. Croci,Germán A Bianco,Germán A Bianco,Marta A. Toscano,Marta A. Toscano,Mariana Salatino,Mariana Salatino,Mónica Vermeulen,Jorge Geffner,Gabriel A. Rabinovich,Gabriel A. Rabinovich,Gabriel A. Rabinovich +13 more
TL;DR: A tolerogenic circuit linking galectin-1 signaling, IL-27-producing DCs and IL-10-secreting T cells is identified, which has broad therapeutic implications in immunopathology.