L
Linda Wang
Researcher at University of Toronto
Publications - 4
Citations - 572
Linda Wang is an academic researcher from University of Toronto. The author has contributed to research in topics: Cell wall & Mutant. The author has an hindex of 4, co-authored 4 publications receiving 557 citations.
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Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations.
Agnes Petit,Toshitaka Kawarai,Erwan Paitel,Nobuo Sanjo,Mary C. Maj,Michael P. Scheid,Fusheng Chen,Yongjun Gu,Hiroshi Hasegawa,Shabnam Salehi-Rad,Linda Wang,Ekaterina Rogaeva,Paul E. Fraser,Brian D. Robinson,Peter St George-Hyslop,Anurag Tandon +15 more
TL;DR: Results suggest that PINK1 reduces the basal neuronal pro-apoptotic activity and protects neurons from staurosporine-induced apoptosis, and loss of this protective function may underlie the degeneration of nigral dopaminergic neurons in patients with Pink1 mutations.
Journal ArticleDOI
Brain levels of CDK5 activator p25 are not increased in Alzheimer's or other neurodegenerative diseases with neurofibrillary tangles
Anurag Tandon,Haung Yu,Linda Wang,Ekaterina Rogaeva,Christine Sato,M. Azhar Chishti,Toshitaka Kawarai,Hiroshi Hasegawa,Fusheng Chen,Peter Davies,Paul E. Fraser,David Westaway,Peter St George-Hyslop +12 more
TL;DR: The data suggest that high Aβ levels in brain do not activate p35 proteolysis, and p25 is unlikely to be a causative agent for NFT formation in AD or other tauopathies.
Journal ArticleDOI
Cell Wall Structure of a Mutant of Mycobacterium smegmatis Defective in the Biosynthesis of Mycolic Acids
TL;DR: The importance of mycolic acids for the structural and functional integrity of the mycobacterial cell wall is demonstrated and the lack of highly organized lipid domains in the mutant cell wall explains the drug-sensitive and temperature-sensitive phenotypes of the mutant.
Journal ArticleDOI
Presenilin 1 and presenilin 2 have differential effects on the stability and maturation of nicastrin in Mammalian brain.
Fusheng Chen,Anurag Tandon,Nobuo Sanjo,Yongjun Gu,Hiroshi Hasegawa,Shigeki Arawaka,Frank S. Lee,Xueying Ruan,Peter Mastrangelo,Serap Erdebil,Linda Wang,David Westaway,Howard T.J. Mount,Howard T.J. Mount,Bruce A. Yankner,Paul E. Fraser,Peter St George-Hyslop,Peter St George-Hyslop +17 more
TL;DR: Although there are differences in the post-translational processing of nicastrin in neurons and glia, both of the presenilins are required for the physiological post- translational modification and for the correct subcellular distribution of Nicastrin.