N
Nobuo Sanjo
Researcher at Tokyo Medical and Dental University
Publications - 91
Citations - 2693
Nobuo Sanjo is an academic researcher from Tokyo Medical and Dental University. The author has contributed to research in topics: Medicine & Disease. The author has an hindex of 19, co-authored 75 publications receiving 2370 citations. Previous affiliations of Nobuo Sanjo include University of California, San Francisco & University of Toronto.
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Journal ArticleDOI
Wild-type PINK1 prevents basal and induced neuronal apoptosis, a protective effect abrogated by Parkinson disease-related mutations.
Agnes Petit,Toshitaka Kawarai,Erwan Paitel,Nobuo Sanjo,Mary C. Maj,Michael P. Scheid,Fusheng Chen,Yongjun Gu,Hiroshi Hasegawa,Shabnam Salehi-Rad,Linda Wang,Ekaterina Rogaeva,Paul E. Fraser,Brian D. Robinson,Peter St George-Hyslop,Anurag Tandon +15 more
TL;DR: Results suggest that PINK1 reduces the basal neuronal pro-apoptotic activity and protects neurons from staurosporine-induced apoptosis, and loss of this protective function may underlie the degeneration of nigral dopaminergic neurons in patients with Pink1 mutations.
Journal ArticleDOI
Quantifying prion disease penetrance using large population control cohorts
Eric Vallabh Minikel,Eric Vallabh Minikel,Sonia M Vallabh,Sonia M Vallabh,Monkol Lek,Monkol Lek,Karol Estrada,Karol Estrada,Kaitlin E. Samocha,Kaitlin E. Samocha,J. Fah Sathirapongsasuti,Cory Y. McLean,Joyce Y. Tung,Linda P.C. Yu,Pierluigi Gambetti,Janis Blevins,Shulin Na Zhang,Yvonne Cohen,Wei Chen,Masahito Yamada,Tsuyoshi Hamaguchi,Nobuo Sanjo,Hidehiro Mizusawa,Yosikazu Nakamura,Tetsuyuki Kitamoto,Steven J. Collins,Alison Boyd,Robert G. Will,Richard Knight,Claudia Ponto,Inga Zerr,Theo F. J. Kraus,Sabina Eigenbrod,Armin Giese,Miguel Calero,Jesús de Pedro-Cuesta,Stéphane Haïk,Jean-Louis Laplanche,Elodie Bouaziz-Amar,Jean Philippe Brandel,Sabina Capellari,Piero Parchi,Anna Poleggi,Anna Ladogana,Anne H. O’Donnell-Luria,Anne H. O’Donnell-Luria,Konrad J. Karczewski,Konrad J. Karczewski,Jamie L. Marshall,Jamie L. Marshall,Michael Boehnke,Markku Laakso,Karen L. Mohlke,Anna K. Kähler,Kimberly Chambert,Steven A. McCarroll,Patrick F. Sullivan,Patrick F. Sullivan,Christina M. Hultman,Shaun Purcell,Pamela Sklar,Sven J. van der Lee,Annemieke J. M. Rozemuller,Casper Jansen,Albert Hofman,Robert Kraaij,Jeroen van Rooij,M. Arfan Ikram,André G. Uitterlinden,Cornelia M. van Duijn,Mark J. Daly,Mark J. Daly,Daniel G. MacArthur,Daniel G. MacArthur +73 more
TL;DR: It is shown that missense variants in PRNP previously reported to be pathogenic are at least 30 times more common in the population than expected on the basis of genetic prion disease prevalence, a finding that supports the safety of therapeutic suppression of prion protein expression.
Journal ArticleDOI
TMP21 is a presenilin complex component that modulates gamma-secretase but not epsilon-secretase activity.
Fusheng Chen,Hiroshi Hasegawa,Hiroshi Hasegawa,Gerold Schmitt-Ulms,Toshitaka Kawarai,Christopher Bohm,Taiichi Katayama,Yongjun Gu,Nobuo Sanjo,Nobuo Sanjo,Michael Glista,Ekaterina Rogaeva,Yosuke Wakutani,Raphaëlle Pardossi-Piquard,Xueying Ruan,Anurag Tandon,Frédéric Checler,Philippe Marambaud,Kirk C. Hansen,David Westaway,Peter St George-Hyslop,Peter St George-Hyslop,Paul E. Fraser +22 more
TL;DR: It is reported that TMP21, a member of the p24 cargo protein family, is a component of presenilin complexes and differentially regulates γ- secretase cleavage without affecting ɛ-secretase activity.
Journal Article
Midkine inhibits caspase-dependent apoptosis via the activation of mitogen-activated protein kinase and phosphatidylinositol 3-kinase in cultured neurons.
Kiyoshi Owada,Nobuo Sanjo,Takeshi Kobayashi,Hidehiro Mizusawa,Hisako Muramatsu,Takashi Muramatsu,Makoto Michikawa +6 more
TL;DR: An apoptosis induction system by serum deprivation in primary neuronal cultures isolated from mouse cerebral cortices is established and results indicate that the ERK cascade plays a central role in MK-mediated neuronal survival via inhibition of caspase-3 activation.
Journal ArticleDOI
Prospective 10-year surveillance of human prion diseases in Japan
Ichiro Nozaki,Tsuyoshi Hamaguchi,Nobuo Sanjo,Moeko Noguchi-Shinohara,Kenji Sakai,Yosikazu Nakamura,Takeshi Sato,Tetsuyuki Kitamoto,Hidehiro Mizusawa,Fumio Moriwaka,Yusei Shiga,Yoshiyuki Kuroiwa,Masatoyo Nishizawa,Shigeki Kuzuhara,Takashi Inuzuka,Masatoshi Takeda,Shigetoshi Kuroda,Koji Abe,Hiroyuki Murai,Shigeo Murayama,Jun Tateishi,Ichiro Takumi,Susumu Shirabe,Masafumi Harada,Atsuko Sadakane,Masahito Yamada +25 more
TL;DR: A frequent occurrence of dura mater graft-associated Creutzfeldt-Jakob disease, and unique phenotypes of sporadic Creutzfelder disease and genetic prion diseases related to the characteristic distribution of prion protein gene mutations and polymorphisms in Japan, compared with those in western countries are revealed.