Hiroshi Hasegawa

TL;DR: It is reported here that inherited variants in the SORL1 neuronal sorting receptor are associated with late-onset Alzheimer disease, and it is shown that SOR l1 directs trafficking of APP into recycling pathways and that when SORl1 is underexpressed, APP is sorted into Aβ-generating compartments.

TL;DR: Results suggest that PINK1 reduces the basal neuronal pro-apoptotic activity and protects neurons from staurosporine-induced apoptosis, and loss of this protective function may underlie the degeneration of nigral dopaminergic neurons in patients with Pink1 mutations.

TL;DR: It is reported that TMP21, a member of the p24 cargo protein family, is a component of presenilin complexes and differentially regulates γ- secretase cleavage without affecting ɛ-secretase activity.

TL;DR: It is reported here that endogenous forms of APH-1 are predominantly expressed in intracellular membrane compartments, including the endoplasmic reticulum andcis-Golgi, and thatAPH-11 in particular may have a role in the initial assembly and maturation of presenilin·nicastrin complexes.

TL;DR: It is reported here that nicastrin is most probably a type 1 transmembrane glycoprotein that is expressed at moderate levels in the brain and in cultured neurons and that presenilin-1 interacts preferentially with mature Nicastrin, suggesting that correct trafficking and co-localization of the presenILin complex components are essential for activity.