L
Lindsay T. Sharpe
Researcher at University of Tübingen
Publications - 66
Citations - 4624
Lindsay T. Sharpe is an academic researcher from University of Tübingen. The author has contributed to research in topics: Color vision & Spectral sensitivity. The author has an hindex of 33, co-authored 66 publications receiving 4345 citations. Previous affiliations of Lindsay T. Sharpe include University College London.
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The spectral sensitivities of the middle- and long-wavelength-sensitive cones derived from measurements in observers of known genotype.
TL;DR: Estimates of the human M- and L-cone spectral sensitivities for 2 and 10 degrees dia are derived from new luminous efficiency determinations, and an estimate of the photopic luminosity function [V(lambda)] for 2 degrees dio.
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Total colourblindness is caused by mutations in the gene encoding the alpha-subunit of the cone photoreceptor cGMP-gated cation channel.
Susanne Kohl,Tim Marx,Ian Giddings,Herbert Jägle,Samuel G. Jacobson,Eckhart Apfelstedt-Sylla,Eberhart Zrenner,Lindsay T. Sharpe,Bernd Wissinger +8 more
TL;DR: This is the first report of a colour vision disorder caused by defects other than mutations in the cone pigment genes, and implies at least in this instance a common genetic basis for phototransduction in the three different cone photoreceptors of the human retina.
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Mutations in the CNGB3 gene encoding the β-subunit of the cone photoreceptor cGMP-gated channel are responsible for achromatopsia (ACHM3) linked to chromosome 8q21
Susanne Kohl,Britta Baumann,Martina Broghammer,Herbert Jägle,Paul A. Sieving,Ulrich Kellner,Robert Spegal,Mario Anastasi,Eberhart Zrenner,Lindsay T. Sharpe,Bernd Wissinger +10 more
TL;DR: Using RT-PCR and RACE, the human cDNA homologue, designated CNGB3, was identified and cloned, which encodes an 809 amino acid polypeptide and was present on 11 of 22 disease chromosomes segregating in families.
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The spectral sensitivity of the human short-wavelength sensitive cones derived from thresholds and color matches.
TL;DR: Two methods are used to estimate short-wave (S) cone spectral sensitivity and propose new S-cone spectral sensitivity functions, which are consistent with the color matching data of Stiles and Burch, and other psychophysically measured functions, such as pi 3.
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Rod pathways: the importance of seeing nothing
TL;DR: Psychophysical and electroretinographic studies in normal observers and in two rare types of observer support an analogous duality in the human visual system, the clearest signature of which is a loss of flicker visibility and ERG amplitude at frequencies near 15 Hz that results from destructive interference between sensitive 'slow' and insensitive 'fast' rod signals.