L
Lindsey S. Marmont
Researcher at University of Toronto
Publications - 19
Citations - 1198
Lindsey S. Marmont is an academic researcher from University of Toronto. The author has contributed to research in topics: Biofilm & Biofilm matrix. The author has an hindex of 11, co-authored 19 publications receiving 859 citations. Previous affiliations of Lindsey S. Marmont include Hospital for Sick Children & Harvard University.
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Journal ArticleDOI
Pel is a cationic exopolysaccharide that cross-links extracellular DNA in the Pseudomonas aeruginosa biofilm matrix
Laura K. Jennings,Kelly M. Storek,Hannah E. Ledvina,Charlène Coulon,Lindsey S. Marmont,Irina Sadovskaya,Patrick R. Secor,Boo Shan Tseng,Michele Scian,Alain Filloux,Daniel J. Wozniak,P. Lynne Howell,Matthew R. Parsek +12 more
TL;DR: A tool for the direct visualization of Pel in biofilms is developed by combining Pel-specific Wisteria floribunda lectin staining with confocal microscopy and the results indicate that Pel cross-links eDNA in the biofilm stalk via ionic interactions.
Journal ArticleDOI
FtsW is a peptidoglycan polymerase that is functional only in complex with its cognate penicillin-binding protein.
Atsushi Taguchi,Michael Welsh,Lindsey S. Marmont,Wonsik Lee,Wonsik Lee,Megan Sjodt,Andrew C. Kruse,Daniel Kahne,Thomas G. Bernhardt,Thomas G. Bernhardt,Suzanne Walker +10 more
TL;DR: Proteidoglycan synthesis was thought to be mediated solely by class A penicillin-binding proteins (PBPs) and related enzymes, a view changed by the identification of RodA as a PG polymerase, but now FtsW is also shown to polymerize PG, in a process that requires complex formation with its partner class B PBP.
Journal ArticleDOI
Structure of the Cytoplasmic Region of PelD, a Degenerate Diguanylate Cyclase Receptor That Regulates Exopolysaccharide Production in Pseudomonas aeruginosa
John C. Whitney,Kelly M. Colvin,Lindsey S. Marmont,Howard Robinson,Matthew R. Parsek,P. Lynne Howell +5 more
TL;DR: It is demonstrated that PelD binds c-di-GMP with low micromolar affinity and that mutation of residues involved in binding not only decreases the affinity of this interaction but also abrogates PEL-specific phenotypes in vivo.
Journal ArticleDOI
Enzymatic modifications of exopolysaccharides enhance bacterial persistence
TL;DR: The diversity of modifications that the EPS alginate, the Pel polysaccharide, Vibrio polysacchide, cepacian, glycosaminoglycans, and poly-N-acetyl-glucosamine undergo during biosynthesis are reviewed.
Journal ArticleDOI
Dimeric c-di-GMP is required for post-translational regulation of alginate production in Pseudomonas aeruginosa.
John C. Whitney,Gregory B. Whitfield,Lindsey S. Marmont,Patrick Yip,A. Mirela Neculai,Yuri D. Lobsanov,Howard Robinson,Dennis E. Ohman,P. Lynne Howell +8 more
TL;DR: The results suggest that the dimeric form of c-di-GMP represents the biologically active signaling molecule needed for the secretion of an important virulence factor produced by P. aeruginosa.