Linghong Chen

TL;DR: The predicted attenuation ofβ-amyloid content in the brain during CR can be reproduced in mouse neurons in vitro by manipulating cellular SIRT1 expression/activity through mechanisms involving the regulation of the serine/threonine Rho kinase ROCK1.

TL;DR: It is found that a naturally derived grape seed polyphenolic extract can significantly inhibit amyloid β-protein aggregation into high-molecular-weight oligomers in vitro and suggests that grape seed-derived polyphenolics may be useful agents to prevent or treat AD.

TL;DR: In this article, the authors identified 7 candidate antihypertensive agents that significantly reduced AD-type beta-amyloid protein (Abeta) accumulation and attenuated the development of Abeta-mediated cognitive deterioration, even when delivered at a dose about 2-fold lower than that used for hypertension treatment in humans.

TL;DR: While it is found that high caloric intake based on saturated fat promotes AD type Beta-amyloidosis, conversely, dietary restriction based on reduced carbohydrate intake is able to prevent it, this evidence is very exciting and is consistent with current epidemiological studies suggesting that obesity and diabetes are associated with a >4-fold increased risk of developing AD.