Liping Xiang

TL;DR: Transferrin receptor 1 (Tfr1) is associated with muscular dysfunction as muscle-specific deletion of Tfr1 results in growth retardation, metabolic disorder, and lethality as mentioned in this paper.

TL;DR: In this article, the authors identified increased expression of Sparcl1, a secreted glycoprotein, in the WAT from NASH mice, and showed that both chronic injection and overexpression of SPARcl1 exaggerated hepatic inflammation and liver injury in mice.

TL;DR: It is shown that 17-hydroxyprogesterone (17-OHP), an intermediate steroid in the biosynthetic pathway that converts cholesterol to cortisol, binds to and stimulates the transcriptional activity of GR, suggesting that selectively targeting hepatic Cyp17A1 may provide a therapeutic avenue for treating T2DM.

TL;DR: Results provide evidence for an unpredicted role of NR2F6 that contributes to liver steatosis and suggest that NR2f6 antagonists may present a therapeutic strategy for reversing or treating NAFLD/NASH pathogenesis.

TL;DR: The results suggest that NAFLD is a heterogeneous disease with highly variable molecular mechanisms, and both distinct and common pathways in the regulation of lipid metabolism from transcriptomes of three mouse models.