Ying Chen

TL;DR: In this article, the authors identified increased expression of Sparcl1, a secreted glycoprotein, in the WAT from NASH mice, and showed that both chronic injection and overexpression of SPARcl1 exaggerated hepatic inflammation and liver injury in mice.

TL;DR: It is shown that 17-hydroxyprogesterone (17-OHP), an intermediate steroid in the biosynthetic pathway that converts cholesterol to cortisol, binds to and stimulates the transcriptional activity of GR, suggesting that selectively targeting hepatic Cyp17A1 may provide a therapeutic avenue for treating T2DM.

TL;DR: Serum GDF15 levels were elevated in patients with hyperthyroidism and declined after thionamide treatment, and Thyroid hormone treatment upregulated GDF 15 expression in mice.

TL;DR: Serum Nrg4 levels were increased in patients with hyperthyroidism, and the liver and white adipose tissue might be primary sources contributing to elevated serum NRG4 concentrations.

TL;DR: Elevated fasting serum fructose levels were independently associated with increased risk of incident type 2 diabetes in a middle-aged and older Chinese population and suggest that higher fasting serumructose levels might serve as a biomarker and/or a contributor to incident diabetes.