Jing Ji

TL;DR: In this article, the authors identified increased expression of Sparcl1, a secreted glycoprotein, in the WAT from NASH mice, and showed that both chronic injection and overexpression of SPARcl1 exaggerated hepatic inflammation and liver injury in mice.

TL;DR: In this article, the EZH2-SOX9-TNFRSF11A axis and the activity of NF-κB signaling in prostate cancer (PCa) cells were analyzed using Limma R package Western blot, real-time PCR and luciferase reporter assays.

TL;DR: In this paper, an E3 ubiquitin ligase was found to be a tumor suppressor in ovarian cancer, and patients with the relatively high expression level of FBXO16 have a better prognosis.

TL;DR: In this article, the authors performed a system-wide investigation of phospho-dependent SKP1-CUL1-F-box (SCF) substrates and identified broad phosphorylation-dependent SCF substrates.

TL;DR: In this paper, the authors showed that UGT8 was selectively highly expressed in non-small cell lung cancer (NSCLC) and associated with worse prognosis, and they showed that inhibition of glycolysis by 2-deoxy-d -glucose (2-DG) significantly impaired the pro-proliferation function of UGT 8 in NSCLC cells.