L
Lisa D.S. Bloomer
Researcher at University of Leicester
Publications - 8
Citations - 335
Lisa D.S. Bloomer is an academic researcher from University of Leicester. The author has contributed to research in topics: Haplogroup & Population. The author has an hindex of 6, co-authored 8 publications receiving 292 citations.
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Journal ArticleDOI
Inheritance of coronary artery disease in men: an analysis of the role of the Y chromosome
Fadi J. Charchar,Lisa D.S. Bloomer,Timothy A. Barnes,Mark J. Cowley,Christopher P. Nelson,Christopher P. Nelson,Yanzhong Wang,Matthew Denniff,Radoslaw Debiec,Paraskevi Christofidou,Scott A Nankervis,Anna F. Dominiczak,Ahmed Bani-Mustafa,Anthony J. Balmforth,Alistair S. Hall,Jeanette Erdmann,François Cambien,Panos Deloukas,Christian Hengstenberg,Chris J. Packard,Heribert Schunkert,Willem H. Ouwehand,Willem H. Ouwehand,Ian Ford,Alison H. Goodall,Alison H. Goodall,Mark A. Jobling,Nilesh J. Samani,Nilesh J. Samani,Maciej Tomaszewski,Maciej Tomaszewski +30 more
TL;DR: Analysis of macrophage transcriptome in the Cardiogenics Study revealed that 19 molecular pathways showing strong differential expression between men with haplogroup I and other lineages of the Y chromosome were interconnected by common genes related to inflammation and immunity, and that some of them have a strong relevance to atherosclerosis.
Journal ArticleDOI
Male-specific region of the Y chromosome and cardiovascular risk: phylogenetic analysis and gene expression studies.
Lisa D.S. Bloomer,Christopher P. Nelson,James Eales,Matthew Denniff,Paraskevi Christofidou,Radoslaw Debiec,Jasbir S. Moore,Ewa Zukowska-Szczechowska,Alison H. Goodall,John F. Thompson,Nilesh J. Samani,Fadi J. Charchar,Maciej Tomaszewski +12 more
TL;DR: Coronary artery disease predisposing haplogroup I of the Y chromosome is associated with downregulation of UTY and PRKY genes in macrophages but not with conventional cardiovascular risk factors.
Journal ArticleDOI
Sexual dimorphism of abdominal aortic aneurysms: a striking example of "male disadvantage" in cardiovascular disease.
TL;DR: The majority of risk factors for AAA exhibit sexual dimorphism but no single risk factor shows a higher magnitude of "male disadvantage" than AAA itself, which suggests that the additive effects ofrisk factors may better explain the higher prevalence of AAA in men than women compared to each individual factor.
Journal ArticleDOI
Coronary artery disease predisposing haplogroup I of the Y chromosome, aggression and sex steroids--genetic association analysis.
Lisa D.S. Bloomer,Christopher P. Nelson,Christopher P. Nelson,Matthew Denniff,Paraskevi Christofidou,Radoslaw Debiec,John F. Thompson,Ewa Zukowska-Szczechowska,Nilesh J. Samani,Nilesh J. Samani,Fadi J. Charchar,Fadi J. Charchar,Maciej Tomaszewski,Maciej Tomaszewski +13 more
TL;DR: The data suggest that the previously identified association between haplogroup I and coronary artery disease is not likely mediated by unfavourable profile of sex steroids or heightened aggression early in life.
Journal ArticleDOI
The Epithelial Sodium Channel γ-Subunit Gene and Blood Pressure: Family Based Association, Renal Gene Expression, and Physiological Analyses
Cara J Busst,Lisa D.S. Bloomer,Katrina J Scurrah,Justine A. Ellis,Timothy A. Barnes,Fadi J. Charchar,Fadi J. Charchar,Peter S. Braund,Paul N. Hopkins,N J Samani,Steven C. Hunt,Maciej Tomaszewski,Maciej Tomaszewski,Stephen B. Harrap +13 more
TL;DR: Genetic and phenotypic evidence is provided in support of a role for a common genetic variant of SCNN1G in blood pressure determination and relationships between the genotypes and relevant intermediate renal phenotypes.