L
Lisa M. Floering
Researcher at Research Triangle Park
Publications - 8
Citations - 1675
Lisa M. Floering is an academic researcher from Research Triangle Park. The author has contributed to research in topics: Protein kinase A & Superoxide. The author has an hindex of 8, co-authored 8 publications receiving 1550 citations. Previous affiliations of Lisa M. Floering include Duke University.
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Journal ArticleDOI
p38 Mitogen-Activated Protein Kinase Is the Central Regulator of Cyclic AMP-Dependent Transcription of the Brown Fat Uncoupling Protein 1 Gene
Wenhong Cao,Kiefer W. Daniel,Jacques Robidoux,Pere Puigserver,Alexander V. Medvedev,Xu Bai,Lisa M. Floering,Bruce M. Spiegelman,Sheila Collins +8 more
TL;DR: It is demonstrated that by orchestrating the activity of multiple transcription factors, p38 MAPK is a central mediator of the cAMP signaling mechanism of brown fat that promotes thermogenesis.
Journal ArticleDOI
Reactive Oxygen Species as a Signal in Glucose-Stimulated Insulin Secretion
Jingbo Pi,Yushi Bai,Qiang Zhang,Victoria A. Wong,Lisa M. Floering,Kiefer W. Daniel,Jeffrey M. Reece,Jude T. Deeney,Melvin E. Andersen,Barbara E. Corkey,Sheila Collins +10 more
TL;DR: Findings suggest that H2O2 derived from glucose metabolism is one of the metabolic signals for insulin secretion, whereas oxidative stress may disturb its signaling function.
Journal ArticleDOI
p38 mitogen-activated protein kinase plays a stimulatory role in hepatic gluconeogenesis
Wenhong Cao,Wenhong Cao,Qu Fan Collins,Thomas C. Becker,Jacques Robidoux,Edgar G. Lupo,Yan Xiong,Kiefer W. Daniel,Lisa M. Floering,Sheila Collins,Sheila Collins +10 more
TL;DR: The results from in vitro and in vivo studies define a model in which cAMP-dependent activation of genes involved in gluconeogenesis is dependent upon the p38 pathway, thus adding a new player to the evolving understanding of this physiology.
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Persistent Nuclear Factor-κB Activation in Ucp2-/- Mice Leads to Enhanced Nitric Oxide and Inflammatory Cytokine Production
Yushi Bai,Hiroki Onuma,Xu Bai,Alexander Medvedev,Mary A. Misukonis,J. Brice Weinberg,Wenhong Cao,Jacques Robidoux,Lisa M. Floering,Kiefer W. Daniel,Sheila Collins +10 more
TL;DR: It is concluded that mitochrondrially derived reactive oxygen from Ucp2-/- cells constitutively activates NF-κB, resulting in a “primed” state to both potentiate and amplify the inflammatory response upon subsequent stimulation.
Journal ArticleDOI
Regulation of the Uncoupling Protein-2 Gene in INS-1 β-Cells by Oleic Acid
Alexander Medvedev,Jacques Robidoux,Xu Bai,Wenhong Cao,Lisa M. Floering,Kiefer W. Daniel,Sheila Collins +6 more
TL;DR: UCP2 mRNA and protein levels were increased after a 48-h exposure of INS-1(832/13) β-cells to oleic acid by activation of the UCP2 promoter, which supports a model in which SREBP is the major modulator of U CP2 gene transcription by FFA, while E-Box binding factors play a supportive role.