L
Lisa R. Leon
Researcher at United States Army Research Institute of Environmental Medicine
Publications - 107
Citations - 6548
Lisa R. Leon is an academic researcher from United States Army Research Institute of Environmental Medicine. The author has contributed to research in topics: Stroke & Hyperthermia. The author has an hindex of 35, co-authored 98 publications receiving 5626 citations. Previous affiliations of Lisa R. Leon include United States Department of the Army & National Institutes of Health.
Papers
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Journal ArticleDOI
Global risk of deadly heat
Camilo Mora,B. Dousset,Iain R. Caldwell,Farrah E. Powell,Rollan C. Geronimo,Coral R. Bielecki,Chelsie W. W. Counsell,Bonnie S. Dietrich,Emily T. Johnston,Leo V. Louis,Matthew P. Lucas,Marie M. McKenzie,Alessandra G. Shea,Han Tseng,Thomas W. Giambelluca,Lisa R. Leon,Ed Hawkins,Clay Trauernicht +17 more
TL;DR: In this article, the authors conducted a global analysis of documented lethal heat events to identify the climatic conditions associated with human death and then quantified the current and projected occurrence of such deadly conditions worldwide.
OtherDOI
Integrated Physiological Mechanisms of Exercise Performance, Adaptation, and Maladaptation to Heat Stress
TL;DR: The "traditional" notion that high core temperature is the critical mediator of exercise performance degradation and heat stroke is questioned, to perhaps explain heat stroke cases reported in low-risk populations performing routine activities.
Journal ArticleDOI
Lack of obesity and normal response to fasting and thyroid hormone in mice lacking uncoupling protein-3.
Da-Wei Gong,Shadi Monemdjou,Oksana Gavrilova,Lisa R. Leon,Bernice Marcus-Samuels,Chieh J. Chou,Carrie Everett,Leslie P. Kozak,Cuiling Li,Chu-Xia Deng,Mary-Ellen Harper,Marc L. Reitman +11 more
TL;DR: The phenotype of UCP1/UCP3 double knockout mice was indistinguishable fromUcp1 single knockout mice, suggesting that UCP3 is not a major determinant of metabolic rate but, rather, has other functions.
Journal ArticleDOI
Heat stroke: Role of the systemic inflammatory response
Lisa R. Leon,Bryan G. Helwig +1 more
TL;DR: Current clinical and experimental evidence suggests a complex interplay between heat cytotoxicity, coagulation, and the systemic inflammatory response syndrome (SIRS) that ensues following damage to the gut and other organs.
Journal ArticleDOI
The adaptive value of fever
TL;DR: There is overwhelming evidence in favor of fever being an adaptive host response to infection that has persisted throughout the animal kingdom for hundreds of millions of years and it is probable that the use of antipyretic/anti-inflammatory/analgesic drugs, when they lead to suppression of fever, results in increased morbidity and mortality during most infections.