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Wieslaw Kozak
Researcher at Nicolaus Copernicus University in Toruń
Publications - 94
Citations - 4167
Wieslaw Kozak is an academic researcher from Nicolaus Copernicus University in Toruń. The author has contributed to research in topics: Inflammation & Prostaglandin E2. The author has an hindex of 31, co-authored 94 publications receiving 3944 citations. Previous affiliations of Wieslaw Kozak include University of Michigan & Lovelace Respiratory Research Institute.
Papers
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Journal ArticleDOI
Resistance to fever induction and impaired acute-phase response in interleukin-1β-deficient mice
Hui Zheng,Daniel S. Fletcher,Wieslaw Kozak,Minghao Jiang,Kathryn J. Hofmann,Carole A. Corn,Darlusz Soszynski,Christina Grabiec,Myrna E. Trumbauer,Alan Shaw,Matthew J. Kostura,Karla Stevens,Hugh Rosen,Robert J. North,Howard Y. Chen,Michael J. Tocci,Matthew J. Kluger,Lex H.T. Van der Ploeg +17 more
TL;DR: A central role for IL-1 beta as a pyrogen and a mediator of the acute-phase response in a subset of inflammatory disease models is highlighted, and the notion that blocking the action of a single key cytokine can alter the course of specific immune and inflammatory responses is supported.
Journal ArticleDOI
Immunomodulatory effects of cigarette smoke
Mohan L. Sopori,Wieslaw Kozak +1 more
TL;DR: Chronic exposure to cigarette smoke or nicotine causes T cell unresponsiveness, which may account for or contribute to the immunosuppressive and anti-inflammatory properties of cigarette smoke/nicotine.
Journal ArticleDOI
The adaptive value of fever
TL;DR: There is overwhelming evidence in favor of fever being an adaptive host response to infection that has persisted throughout the animal kingdom for hundreds of millions of years and it is probable that the use of antipyretic/anti-inflammatory/analgesic drugs, when they lead to suppression of fever, results in increased morbidity and mortality during most infections.
Journal ArticleDOI
Role of Fever in Disease
TL;DR: It is speculated that patients who would not have survived severe sepsis in the past are now being kept alive and that the occasionally high fevers seen in these patients may be maladaptive.
Journal ArticleDOI
IL-6 and IL-1 beta in fever. Studies using cytokine-deficient (knockout) mice.
Wieslaw Kozak,Matthew J. Kluger,Dariusz Soszynski,Carole A. Conn,Karin Rudolph,Lisa R. Leon,Hui Zheng,Hui Zheng +7 more
TL;DR: The data demonstrate that in the mouse, IL‐1β and IL‐6 are critical for the induction of fever during local inflammation, whereas in systemic inflammation they appear only to contribute to fever.