Yu Zhou

TL;DR: The results reveal distinct host inflammatory cytokine profiles to SARS-CoV-2 infection in patients, and highlight the association between COVID-19 pathogenesis and excessive cytokine release such as CCL2/MCP-1, CXCL10/IP-10, CCL3/MIP-1A, and CCL4/Mip1B.

TL;DR: It is reported that repression of a single RNA binding polypyrimidine-tract-binding protein is sufficient to induce trans-differentiation of fibroblasts into functional neurons and has a previously undocumented function in the regulation of microRNA functions, suppressing or enhancing microRNA targeting by competitive binding on target mRNA or altering local RNA secondary structure.

TL;DR: A mechanism for PTB to modulate splice site competition to produce opposite functional consequences is suggested, which may be generally applicable to RNA-binding splicing factors to positively or negatively regulate alternative splicing in mammalian cells.

TL;DR: It is reported that miR-1, a microRNA specifically induced during myogenesis, efficiently enters the mitochondria where it unexpectedly stimulates, rather than represses, the translation of specific mitochondrial genome-encoded transcripts.

TL;DR: It is demonstrated that a piRNA-induced silencing complex (pi-RISC) containing murine PIWI and deadenylase CAF1 is selectively assembled in ES, which is responsible for inducing mRNAdeadenylation and decay via a mechanism that resembles the action of miRNAs in somatic cells.