L
Loan Nguyen
Researcher at Stanford University
Publications - 9
Citations - 1767
Loan Nguyen is an academic researcher from Stanford University. The author has contributed to research in topics: Promoter & Gene. The author has an hindex of 9, co-authored 9 publications receiving 1721 citations.
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Journal ArticleDOI
A genomic screen of autism: evidence for a multilocus etiology.
Neil Risch,Donna Spiker,Linda Lotspeich,Nassim Nouri,David A. Hinds,Joachim Hallmayer,Luba Kalaydjieva,Patty McCague,Sue Dimiceli,Tawna Pitts,Loan Nguyen,Joan Yang,Courtney Harper,Danielle Thorpe,Saritha Vermeer,Helena Young,Joan M. Hebert,A. A. Lin,Joan Ferguson,Carla Chiotti,Susan Wiese-Slater,Tamara Rogers,Boyd Salmon,Peter Nicholas,P. Brent Petersen,C. Pingree,William M. McMahon,Dona L. Wong,Luigi Luca Cavalli-Sforza,Helena C. Kraemer,Richard M. Myers +30 more
TL;DR: The results suggest that positional cloning of susceptibility loci by linkage analysis may be a formidable task and that other approaches may be necessary.
Journal ArticleDOI
Distinct DNA methylation patterns characterize differentiated human embryonic stem cells and developing human fetal liver.
Alayne L. Brunner,David S. Johnson,Si Wan Kim,Anton Valouev,Timothy E. Reddy,Norma F. Neff,Elizabeth Anton,Catherine Medina,Loan Nguyen,Eric Chiao,Chuba Oyolu,Gary P. Schroth,Devin Absher,Julie C. Baker,Richard M. Myers +14 more
TL;DR: The results indicate that hESC differentiation has a unique DNA methylation signature that may not be indicative of in vivo differentiation, and these regions become highly unmethylated, which is a distinct trend from that observed in hESCs.
Journal ArticleDOI
Comprehensive analysis of transcriptional promoter structure and function in 1% of the human genome
TL;DR: The largest and most comprehensive view of promoter function in the human genome is provided, showing a strong correlation between promoter activity and the corresponding endogenous RNA transcript levels, providing the first experimental quantitative estimate of promoter contribution to gene regulation.
Journal ArticleDOI
Systematic evaluation of variability in ChIP-chip experiments using predefined DNA targets
David S. Johnson,Wei Li,Wei Li,D. Benjamin Gordon,Arindam Bhattacharjee,Bo Curry,Jayati Ghosh,Leonardo Brizuela,Jason S. Carroll,Myles Brown,Paul Flicek,Christoph M. Koch,Ian Dunham,Mark Bieda,Xiaoqin Xu,Peggy J. Farnham,Philipp Kapranov,David A. Nix,Thomas R. Gingeras,Xinmin Zhang,H. Holster,Nan Jiang,Roland Green,Jun S. Song,Scott McCuine,Elizabeth Anton,Loan Nguyen,Nathan D. Trinklein,Zhen Ye,Keith A. Ching,David Hawkins,Bing Ren,Peter C. Scacheri,Joel Rozowsky,Alexander Karpikov,Ghia Euskirchen,Sherman M. Weissman,Mark Gerstein,Michael Snyder,Annie Yang,Zarmik Moqtaderi,Heather A. Hirsch,Hennady P. Shulha,Yutao Fu,Zhiping Weng,Kevin Struhl,Richard M. Myers,Jason D. Lieb,X. Shirley Liu +48 more
TL;DR: The first objective analysis of tiling array platforms, amplification procedures, and signal detection algorithms in a simulated ChIP-chip experiment is conducted, finding that microarray platform choice is not the primary determinant of overall performance.
Journal ArticleDOI
Lack of evidence for an association between WNT2 and RELN polymorphisms and autism
Jun Li,Loan Nguyen,Christopher Gleason,Linda Lotspeich,Donna Spiker,Neil Risch,Richard M. Myers +6 more
TL;DR: It is unlikely that DNA variations in RELN and WNT2 play a significant role in the genetic predisposition to autism, according to the null hypothesis of no association.